The Study for the Correlation Between the Clinical Results and Neovascularigation and bFGF Expression in Disc Herniation

Jeon, Chang Hoon; Kim, Han Kyeom; Khang, Shin Young

Abstract

STUDY DESIGN: To study the correlation between the clinical outcomes and neovascularization and bFGF expression in the herniated disc tissues.
OBJECTIVES
To study the difference of neovascularization and bFGF expression according to the types of disc herniation, and to study the correlation between the duration of radiculopathy, post-operative results and neovascularization and bFGF expression in the herniated disc tissues. SUMMARY OF LITERATURE REVIEW: Neovascularization has been found in herniated disc tissue. bFGF(basic Fibroblast Growth Factor) in the intervertebral disc has been implicated in the pathogenesis of injury and repair associated with granulation and neovascularization. There is no information on the relationship between clinical outcome and the neovascularization and bFGF expression in the herniated disc tissue.
MATERIALS AND METHODS
Among 112 specimens, there are 48 cases in protrusion, 36 in extrusion and 28 in sequestration. Hematoxylin-eosin stain and immunochemical stain with CD 31 and bFGF were used. For the evaluation of post-operative results, Kirkaldy-Willis method was used. The results were analyzed with Chisquare test and t-test.
RESULTS
Statistically there is no correlation between the types of disc herniation, duration of radiculopathy and post-operative outcomes and neovascularization and bFGF expression.
CONCLUSIONS
The neovascularization and bFGF expression in herniated disc tissue are correlated with the injury of disc tissue. There are no correlation with the clinical outcomes and neovascularization and bFGF expression in herniated disc tissues.