J Korean Surg Soc.
2000 Dec;59(6):746-750.
The Expression of bFGF m-RNA in Gastric Cancer Tissues
- Affiliations
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- 1Department of Surgery, College of Medicine, Seoul National University.
- 2Department of Surgery, College of Medicine, Ewha Womans University, Seoul, Korea.
Abstract
- PURPOSE: The production of basic fibroblast growth factor (bFGF) which is known to have a strong angiogenic activity in gastric cancer, was evaluated. METHODS: Using alkaline phosphoatase - labelled, synthetic oligonucleotide probe of bFGF genes, the expression of the gene was evaluated in 9 fresh advanced gastric cancer tissues by using in-situ hybridization. RESULTS: In-situ hybridization of bFGF mRNA showed a positive reaction in 8 of 9 patients. CONCLUSION: Basic fibroblast growth factor is expressed in 88% of gastric cancer tissues. In view of the profuse expression of angiogenic growth factor, future therapeutic targeting for angiogenesis could be reasonable in patients with gastric cancer.
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