Ann Surg Treat Res.  2014 Apr;86(4):184-191. 10.4174/astr.2014.86.4.184.

Outcomes of living donor liver transplantation using elderly donors

• Han JH
• You YK
• Na GH
• Kim EY
• Lee SH
• Hong TH
• Kim DG

• KMID: 2167124
• DOI: http://doi.org/10.4174/astr.2014.86.4.184

Abstract

PURPOSE
Living donor liver transplantation (LDLT) using elderly donors is increasing in frequency in response to organ shortage. However, elderly donor graft has been reported to negatively affect graft patency and patient survival.
METHODS
We retrospectively reviewed the medical records of 604 patients who underwent LDLT at Seoul St. Mary's Hospital, The Catholic University of Korea between May 1999 and September 2012. Elderly donors were defined as those > or =55 years of age. Here, we evaluate the survival differences and causes of death of recipients of elderly donor grafts.
RESULTS
The overall mortality rate of the recipients was significantly higher in the elderly donor group (group A) than in the younger donor group (group B: 46.2% vs. 18.1%, P = 0.004). The survival length of group A was significantly shorter than that of group B (31.2 +/- 31.3 and 51.4 +/- 40.8 months, P = 0.014). The significantly common causes of death in group A were biliary (41.7%) and arterial complication (16.7%), and it was higher than those in group B (P = 0.000 and P = 0.043, respectively).
CONCLUSION
LDLT using elderly donors could induce more serious complications and higher mortality rates than those at using younger donors. As such, careful donor selection is needed, especially with regard to assessing the condition of potential elderly donor livers. Furthermore, a large-volume and multicenter study of complications and outcomes of LDLT using elderly donor liver is required.

Keyword

Liver transplantation; Living donor; Survival; Prognosis

MeSH Terms

Aged*
Cause of Death
Donor Selection
Humans
Korea
Liver Transplantation*
Liver*
Living Donors*
Medical Records
Mortality
Prognosis
Retrospective Studies
Seoul
Tissue Donors*
Transplants

Figure

• 

  Fig. 1 Kaplan-Meier survival curves of the recipients (P < 0.001) in living donor liver transplantation. Group A, recipients of livers from elderly donors (≥55 years of age); group B, recipients of livers from younger donors (<55 years of age).

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