Exp Neurobiol.  2008 Dec;17(2):41-46. 10.5607/en.2008.17.2.41.

Striatal CREB Phosphorylation Following Cued/Response Learning in the Water Maze Differ in Two Inbred Strains of Mice

  • 1Department of Biological Sciences & Center for Geriatric Neuroscience Research, IBST, Konkuk University, Seoul 143-701, Korea. jshan06@konkuk.ac.kr


Much evidence shows that the hippocampus and striatum play roles as important neural substrates for spatial/place and cued/response learning, respectively. This experiment was conducted to investigate the engagement of the striatum in cued/response learning. The engagement of the striatum was assessed after either place or cue training by determining levels of cAMP response element-binding protein (CREB) and phosphorylated CREB (pCREB) in these two mouse strains. Results revealed that striatal CREB levels in both strains of mice were not significantly increased after cued/response learning comparing to place training mediated by the hippocampus. However, striatal pCREB of DBA/2 mice was significantly higher after cued/response training in comparison to place learning, while striatal pCREB levels on C57BL/6 mice did not differ in cued learning versus place learning. These findings indicate that striatal pCREB, specifically associated with cued/response learning, is closely tied to differences in cued/responses strategy preference between C57BL/6 and DBA/2 mice.


cAMP response element-binding protein; pCREB; place learning; cued/response learning; striatum; water maze
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