- Activation of PKCdelta by tyrosine phosphorylation in rat parotid acinar cells
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Benes C, Zheng Y, Soltoff SP
- KMID: 1026946
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S40-S41.
- doi: 10.3346/jkms.2000.15.S.S40
Receptor- and nonreceptor-mediated stimuli produce increases in both PKCdelta tyrosine phosphorylation and activity in rat parotid acinar cells and other cells. In vivo and in vitro increases and decreases in... -
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- Fyn Tyrosine Kinase-mediated Tyrosine Phosphorylation of Roundabout (Robo), the Slit Receptor
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Jeon ES, Bae KW, Park HT
- KMID: 2224507
- Korean J Anat.
- 2004 Jun;37(3):275-281.
In this study, the molecular mechanism of tyrosine phosphorylation of Roundabout (Robo), the transmembrane receptor for slits, was investigated. The tyrosine phosphorylation of intracellular portion of Robo was increased by... -
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- Multiple Regulation of Roundabout (Robo) Phosphorylation in a Heterologous Cell System
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Park HT
- KMID: 1611238
- Korean J Physiol Pharmacol.
- 2004 Apr;8(2):111-115.
Roundabout (Robo) is the transmembrane receptor for slit, the neuronal guidance molecule. In this study, the tyrosine phosphorylation of Robo was observed in Robo-transfected human embryonic kidney cells and developing... -
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- Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases
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Patel MS, Korotchkina LG
- KMID: 1457529
- Exp Mol Med.
- 2001 Dec;33(4):191-197.
This review summarizes the recent developments on the regulation of human pyruvate dehydrogenase complex (PDC) by site-specific phosphorylation by four kinases. Mutagenic analysis of the three phosphorylation sites of human... -
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- Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein
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Hong KU, Kim HJ, Bae CD, Park J
- KMID: 1122284
- Exp Mol Med.
- 2009 Nov;41(11):832-840.
- doi: 10.3858/emm.2009.41.11.089
Tumor-associated microtubule-associated protein (TMAP), also known as cytoskeleton associated protein 2 (CKAP2), has been recently shown to be involved in the assembly and maintenance of mitotic spindle and also plays... -
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- GLUT phosphorylation may be required to GLUT translocation mechanism
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Hah JS
- KMID: 1581028
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):497-506.
In this work, GLUTs phosphorylations by a downstream effector of PI3-kinase, PKC- zeta, were studied, and GLUT4 phosphorylation was compared with GLUT2 phosphorylation in relation to the translocation mechanism. Prior to phosphorylation experiment,... -
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- Myoplasmic [Ca2+], Crossbridge Phosphorylation and Latch in Rabbit Bladder Smooth Muscle
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Kim YD, Cho MH, Kwon SC
- KMID: 1448921
- Korean J Physiol Pharmacol.
- 2011 Jun;15(3):171-177.
- doi: 10.4196/kjpp.2011.15.3.171
Tonic smooth muscle exhibit the latch phenomenon: high force at low myosin regulatory light chains (MRLC) phosphorylation, shortening velocity (Vo), and energy consumption. However, the kinetics of MRLC phosphorylation and... -
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- Phosphorylation of ribosomal protein S6 and its regulation during differentiation of human leukemic cells
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Kim IS, Lee SB, Cho KC
- KMID: 1422012
- J Korean Med Sci.
- 1993 Dec;8(6):413-419.
- doi: 10.3346/jkms.1993.8.6.413
We attempted to study the role of protein tyrosine kinase (PTK) and protein kinase C (PKC) in the cascade of phosphorylation of ribosomal protein S6 during differentiation of leukemic cells... -
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- Phosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal Transition
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Kim HJ, Choi WJ, Lee CH
- KMID: 2382358
- Biomol Ther.
- 2015 Jul;23(4):301-312.
- doi: 10.4062/biomolther.2015.032
Metastasis is one of hallmarks of cancer and a major cause of cancer death. Combatting metastasis is highly challenging. To overcome these difficulties, researchers have focused on physical properties of... -
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- Regulation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B activity by casein kinase II- and p56lck-mediated phosphorylation
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Kang KR, Kim CW
- KMID: 927134
- Exp Mol Med.
- 2000 Mar;32(1):47-51.
Protein tyrosine phosphorylation and dephosphorylation are important in the regulation of cell proliferation and signaling cascade. In order to examine whether phosphatase activity of CPTP1 and HPTP1B, typical nontransmembrane protein... -
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- 12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2
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Lee EJ, Park MK, Kim HJ, Kang JH, Kim YR, Kang GJ, Byun HJ, Lee CH
- KMID: 2170651
- Biomol Ther.
- 2014 Mar;22(2):122-128.
The stiffness of cancer cells is attributable to intermediate filaments such as keratin. Perinuclear reorganization via phosphorylation of specific serine residue in keratin is implicated in the deformability of metastatic... -
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- p53-mediated HIV-1 Tat Suppression is Likely to be Assaciated with duble-stranded RNA-dependent Protein Kinase, PKR
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Kim JW, Byun HS, Bae YS
- KMID: 1544230
- J Korean Soc Virol.
- 1999 Dec;29(4):235-245.
No abstract available. -
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- Phosphorylation of chicken protein tyrosine phosphatase 1 by casein kinase II in vitro
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Jung EJ, Kang KR, Kang YS
- KMID: 1532667
- Exp Mol Med.
- 1997 Dec;29(4):229-233.
The phosphorylation and dephosphorylation of proteins on tyrosyl residues are key regulatory mechanisms of cell growth and signal transduction and are controlled by opposing activities of protein tyrosine kinases and... -
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- AMPA, not NMDA, activates RhoA GTPases and subsequetly phosphorylates moesin
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Kim SJ, Jeon S, Shin EY, Kim EG, Park J, Bae CD
- KMID: 755672
- Exp Mol Med.
- 2004 Feb;36(1):98-102.
Glutamate induced rapid phosphorylation of moesin, one of ERM family proteins involved in the ligation of membrane to actin cytoskeleton, in rat hippocampal cells (JBC, 277:16576-16584, 2002). However, the identity... -
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- Polyamines Regulate Growth Factor-Induced Protein Phosphorylation in MCF-7 Human Breast Cancer Cells
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Lee JY, Lee KH, Kim BG
- KMID: 2134354
- Cancer Res Treat.
- 2002 Jun;34(3):198-204.
PURPOSE: Growth factors stimulate protein phosphorylation resulting in transmission of mitogenic signals. In breast cancer, protein kinases and their substrate proteins are importnat in cell proliferation and phathogenesis. Polymine is... -
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- IFN-alpha Downregulates ERK Phosphorylation of CD4+ T Lymphocytes in Systemic Lupus Erythematosus
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Yoo WH
- KMID: 2202227
- J Korean Rheum Assoc.
- 2006 Sep;13(3):193-202.
OBJECTIVE: CD4+ T cells from patients with systemic lupus erythematosus (SLE) display aberrant TCR signaling and IFN-alpha plays critical roles in the pathogenesis of SLE; however, the effects of IFN-alpha... -
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- Tyrosine phosphorylation of paxillin may be involved in vascular smooth muscle contraction
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Fang LH, Cho KS, Lee SJ, Ahn HY
- KMID: 1580807
- Korean J Physiol Pharmacol.
- 2000 Jun;4(3):211-217.
Paxillin is a regulatory component of the complex of cytoskeletal proteins that link the actin cytoskeleton to the plasma membrane. However, the role of paxillin during smooth muscle contraction is unclear. We investigated... -
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- The Role of PKCzeta on MT1-MMP Expression with Shear Stress and Cyclic Strain in Microvascular Endothelial Cells
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Yun SS, Kim JI, Moon IS
- KMID: 2096845
- J Korean Soc Vasc Surg.
- 2007 Nov;23(2):120-127.
PURPOSE: hear stress (SS) and cyclic strain (CS) influence the expression of membrane type 1-matrix metalloproteinase (MT1-MMP) in microvascular endothelial cells (MVECs). It is known that changes in the level... -
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- Alfa - difluoromethylornithine Reduced Protein Phosphorylation in MCF-7 Human Breast Cancer Cells
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Lee JY, Kim BK
- KMID: 2059303
- J Korean Cancer Assoc.
- 1999 Oct;31(5):1044-1053.
No abstract available. -
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- Amphetamine-induced ERM Proteins Phosphorylation Is through PKCbeta Activation in PC12 Cells
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Jeong HJ, Kim JH, Jeon S
- KMID: 1448929
- Korean J Physiol Pharmacol.
- 2011 Aug;15(4):245-249.
- doi: 10.4196/kjpp.2011.15.4.245
Amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (DAT) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. Recently, we reported that the phosphorylation... -
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