Brain Neurorehabil.  2015 Sep;8(2):104-108. 10.12786/bn.2015.8.2.104.

Dose-dependent Changes in Gait Pattern after Intrathecal Baclofen Bolus Injection in Adult Ambulatory Cerebral Palsy: A Case Report

Affiliations
  • 1Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Korea. srcho918@yuhs.ac
  • 2Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Korea.
  • 3Department of Neurosurgery and Brain Research Institute, Yonsei University College of Medicine, Korea.
  • 4Avison Biomedical Research Center, Yonsei University College of Medicine, Korea.
  • 5Rehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Korea.

Abstract

Intrathecal baclofen (ITB) therapy has been proven to reduce severe spasticity in cerebral palsy (CP). However, few results reported the objective gait pattern change after ITB bolus injection in adult ambulatory CP. We therefore evaluated observational and kinematic gait patterns at different ITB bolus injection doses. We performed a test trial of 3-day ITB bolus injections at doses of 12.5 microg, 25 microg, and 50 microg in ambulatory CP. We evaluated modified Ashworth scale, visual analogue scale, observational gait scale, and kinematic gait analysis after ITB bolus injection. Intrathecal administration of low-dose baclofen 25 microg was successfully used not only for the treatment of spasticity but also for the treatment of gait disturbance, whereas the higher dose baclofen 50 microg induced foot drop and deteriorated gait pattern. We experienced dose-dependent changes in gait pattern confirmed by the observational and kinematic gait assessments after ITB bolus injection in adult ambulatory CP.

Keyword

baclofen; cerebral palsy; gait
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