J Korean Med Sci.  2012 Dec;27(12):1524-1529. 10.3346/jkms.2012.27.12.1524.

Comparison of Lipid-Related Ratios for Prediction of Chronic Kidney Disease Stage 3 or More in Korean Adults

Affiliations
  • 1Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. hope@yuhs.ac
  • 2Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.

Abstract

Dyslipidemia is implicated in increased cardiovascular risk associated with chronic kidney disease (CKD) and in the progression of renal damage. This study compared 4 different lipid-related ratios (total cholesterol [TC]/high-density lipoprotein cholesterol [HDL-C], triglyceride [TG]/HDL-C, calculated low-density lipoprotein cholesterol [c-LDL-C]/HDL-C, and non-HDL-C/HDL-C ratio) for prediction of CKD stage 3 or more to investigate the association between them. This cross-sectional study included 8,650 adults who participated in the 2007-2008 Korean National Health and Nutrition Examination Survey. The overall prevalence of CKD stage 3 or more was 6.4%. For TG/HDL-C, the prevalence with CKD stage 3 or more increased with increasing quartile group in both sexes (P value for trend = 0.046 in men, 0.002 in women) while other lipid-related ratios showed increasing prevalence only in women. In comparison with the lowest quartile of the lipid-related ratios, only the fourth quartile of TG/HDL-C was associated with the prevalence of CKD stage 3 or more in both sexes after adjustment for multiple covariates (odds ratio [OR] for TG/HDL-C-Q4, 1.82; 95% CI [confidence interval], 1.09-3.03 in men, OR 2.45; 95% CI, 1.52-3.95 in women). In conclusion, TG/HDL-C is the only lipid-related ratio that is independently associated with CKD stage 3 or more in both sexes of Koreans.

Keyword

Kidney Failure, Chronic; Dyslipidemias; Glomerular Filtration Rate

MeSH Terms

Adult
Aged
Asian Continental Ancestry Group
Cholesterol/*blood
Cholesterol, HDL/*blood
Cholesterol, LDL/*blood
Cross-Sectional Studies
Female
Glomerular Filtration Rate
Humans
Male
Middle Aged
Nutrition Surveys
Odds Ratio
Predictive Value of Tests
Prevalence
Renal Insufficiency, Chronic/epidemiology/etiology/*metabolism
Republic of Korea
Risk Factors
*Severity of Illness Index
Triglycerides/*blood
Cholesterol, HDL
Cholesterol, LDL
Triglycerides
Cholesterol
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