J Korean Biol Nurs Sci.  2017 May;19(2):107-112. 10.7586/jkbns.2017.19.2.107.

Comparison of Lipid Profile Ratios in Patients with High-grade Brain Cancers according to the Presence of Recurrence during Cancer-related Therapy

• Kim S

• KMID: 2382109
• DOI: http://doi.org/10.7586/jkbns.2017.19.2.107

Abstract

PURPOSE
The purpose of this study was to identify the lipid profile ratios as factors affecting disease progress in patients with high-grade primary brain cancers undergoing concurrent chemoradiotherapy (CCRT) and adjuvant chemotherapy.
METHODS
The levels of lipid profile ratios were evaluated by looking at the total cholesterol (TC) to high-density lipoprotein (HDL)-cholesterol (TC/HDL-c), low-density lipoprotein (LDL)-cholesterol to HDL-cholesterol (LDL-c/HDL-c), and triglycerides to HDL-cholesterol (TG/HDL-c). This descriptive research was conducted 7 months after the initiation of CCRT and adjuvant chemotherapy.
RESULTS
A total of 36 patients with newly diagnosed primary malignant brain cancer were included in the study. The levels of lipid profile ratios such as TC/HDL-c, LDL-c/HDL-c, TG/HDL-c were significantly different between the patients with and without disease progress at 7 months after initiation of CCRT and adjuvant chemotherapy.
CONCLUSION
The lipid profile ratios were indicators affecting disease prognosis with tumor-related factors at 7 months after initiation of CCRT and adjuvant chemotherapy. Therefore, lipid profile ratios indicating hyperlipidemia in patients with high-grade brain cancers should be carefully monitored during and after cancer-related therapy.

Keyword

High-grade Brain Cancers; Cancer-related Therapy; Lipid Profile Ratios

MeSH Terms

Brain Neoplasms*
Brain*
Chemoradiotherapy
Chemotherapy, Adjuvant
Cholesterol
Humans
Hyperlipidemias
Lipoproteins
Prognosis
Recurrence*
Triglycerides
Cholesterol
Lipoproteins
Triglycerides