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Novel Compound Heterozygous Mutations in CTSC Gene in a Chinese Family with Papillon–Lefevre Syndrome

Wang Y, Zhang H, Feng S

Papillon–Lefevre syndrome (PLS) (OMIM: 245000) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early onset periodontitis, resulting in the premature loss of the deciduous and permanent teeth....
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The Reflux Symptoms Before and After Peroral Endoscopic Myotomy of Chinese Patients With Achalasia

Xu Y, Wang Y, Bao Y, Yu T, Tang Y, Lin L, Jiang L

  • KMID: 2517532
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):377-389.
  • doi: 10.5056/jnm20041
Background/Aims Achalasia is a rare disease, but the incidence is increasing recently. Peroral esophageal myotomy (POEM) is an effective treatment. Regurgitation is a common symptom before and after POEM. Our aim is...
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Asian Conference on Tumor Ablation guidelines for renal cell carcinoma

Park BK, Shen SH, Fujimori M, Wang Y

Thermal ablation has been established as an alternative treatment for renal cell carcinoma (RCC) in patients who are poor candidates for surgery. However, while American and European guidelines have been...
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The Prevalence and Predictors of Obstructive Sleep Apnea in Chinese Bariatric Surgery Candidates: A Single-Center Study

Chen W, Zhang X, Parmar C, Wang Y, Yang W, Pan J, Dong Z, Wang C

Purpose: The purpose of the study is to determine the prevalence and predictors of OSA in Chinese bariatric surgery candidates. Materials and Methods: The clinical data were collected from 326...
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Long Non-Coding RNA RMRP Contributes to Sepsis-Induced Acute Kidney Injury

Zhang X, Huang Z, Wang Y, Wang T, Li J, Xi P

Purpose: This study aimed to explore the role of the long non-coding RNA (lncRNA) RNA component of mitochondrial RNAase P (RMRP) in sepsis-induced acute kidney injury (AKI). Materials and Methods: Venous...
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KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells

Zhu H, Wang Y, Wei T, Zhao X, Li F, Li Y, Wang F, Cai Y, Jin J

Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Imbalanced histone acetylation has been observed in many primary cancers. Therefore, efforts have been...
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Exogenous Local Hyperthermia at 41o C Is Effective to Eliminate Mouse Model of Sporotrichosis, Independent of Neutrophil Extracellular Traps Formation

Wang YL, Qi RQ, Lan J, Li ZX, Gao XH

Background: Local hyperthermia is recommended for the treatment of patients with fixed cutaneous sporotrichosis, though the effectiveness and mechanisms of action remain elusive. While neutrophils represent the main inflammatory cells...
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Effectiveness of a home-based exercise program among patients with lower limb spasticity post-stroke: A randomized controlled trial

Chen S, Lv C, Wu J, Zhou C, Shui X, Wang Y

Purpose To evaluate the effectiveness of advanced practice nurse–guided home-based rehabilitation exercise program (HREPro) among patients with lower limb spasticity post-stroke. Methods This randomized controlled study recruited 121 patients with lower limb spasticity...
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Moving Rate of Positive Patient Results as a Quality Control Tool for High-Sensitivity Cardiac Troponin T Assays

Li T, Cao S, Wang Y, Xiong Y, He Y, Ke P, Huang X

Background: A small shift in high-sensitivity cardiac troponin T (hs-cTnT) assays can lead to different result interpretation and consequent patient management. We explored whether a small bias could be detected...
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The changes of immune-related molecules within the ileal mucosa of piglets infected with porcine circovirus type 2

Shi F, Li Q, Zou Z, Wang Y, Hou X, Zhang Y, Song Q, Zhou S, Li H

Background: Enteritis is one of the most frequently reported symptoms in piglets infected with porcine circovirus type 2 (PCV2), but the immunopathogenesis has not been reported. Objectives: This study examined the...
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Curcumin targets vascular endothelial growth factor viaactivating the PI3K/Akt signaling pathway and improves brainhypoxic-ischemic injury in neonatal rats

Li J, An Y, Wang JN, Yin XP, Zhou H, Wang YS

This study aimed to evaluate the effect of curcumin on brain hypoxicischemic(HI) damage in neonatal rats and whether the phosphoinositide 3-kinase(PI3K)/Akt/vascular endothelial growth factor (VEGF) signaling pathway is involved.Brain HI...
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MiR-542-5p Inhibits Hyperglycemia and Hyperlipoidemia by Targeting FOXO1 in the Liver

Tian F, Ying HM, Wang YY, Cheng BN, Chen J

Purpose: This research was designed to investigate how miR-542-5p regulates the progression of hyperglycemia and hyperlipoidemia. Materials and Methods: An in vivo model with diabetic db/db mice and an in vitro...
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Thyroid fine-needle aspiration cytology in Taiwan: a nationwide survey and literature update

Chen CC, Hang JF, Liu CY, Wang YH, Lai CR

In Taiwan, thyroid fine-needle aspiration cytology is easily accessible and reliable for evaluating thyroid nodules. The sonographic pattern plays a major role and is the deciding factor for aspiration. We...
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Continuity of Care in Chronic Diseases: A Concept Analysis by Literature Review

Hu J, Wang Y, Li X

Purpose: This study aimed to utilize concept analysis to obtain a better understanding of the concept of “continuity of care” in chronic diseases. Methods: The concept of continuity of care...
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The Practice of Gastrointestinal Motility Laboratory During COVID-19 Pandemic: Position Statements of the Asian Neurogastroenterology and Motility Association (ANMA-GML-COVID-19 Position Statements)

Siah KTH, Rahman MM, Ong AML, Soh AYS, Lee YY, Xiao Y, Sachdeva S, Jung KW, Wang YP, Oshima T, Patcharatrakul T, Tseng PH, Goyal O, Pang J, Lai CKC, Park JH, Mahadeva S, Cho YK, Wu JCY, Ghoshal UC, Miwa H

  • KMID: 2503998
  • J Neurogastroenterol Motil.
  • 2020 Jul;26(3):299-310.
  • doi: 10.5056/jnm20107
During the Coronavirus Disease 2019 (COVID-19) pandemic, practices of gastrointestinal procedures within the digestive tract require special precautions due to the risk of contraction of severe acute respiratoy syndrome coronavirus-2...
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Brain Imaging Study on the Pathogenesis of Depression & Therapeutic Effect of Selective Serotonin Reuptake Inhibitors

Meng Q, Zhang A, Cao X, Sun N, Li X, Zhang Y, Wang Y

Objective Predefining the most effective treatment for patients with depressive disorders remains a problem. We will examine the differential brain regions of gray matter (GM) in major depressive disorder (MDD)...
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Recommendations on management of gynecological malignancies during the COVID-19 pandemic: perspectives from Chinese gynecological oncologists

Wang Y, Zhang S, Wei L, Lin Z, Wang X, Wang J, Hua K, Cui M, Wang J, Wang S, Di W, Wang Y, An R, Xi M, Guo R, Zhou Q, Xie X, Xue F

The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 has rapidly spread globally. Cancer patients are at a higher risk of being infected...
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Proliferation, Differentiation and Immunoregulatory Capacities of Brown and White Adipose-Derived Stem Cells from Young and Aged Mice

Yang YM, Dong XH, Ma WC, Guan LH, Wang YH, Huang XH, Chen JF, Zhao X, Yang SM, Jiang XX, Wen N

Background and Objectives: Adipose tissue is a source of mesenchymal stem cells, which have the potential to differentiate into various types of cells. Adipose-derived stem cells (ADSCs) are now recognized...
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Prognostic Value of TP53 Mutation for Transcatheter Arterial Chemoembolization Failure/Refractoriness in HBV-Related Advanced Hepatocellular Carcinoma

Xue M, Wu Y, Fan W, Guo J, Wei J, Wang H, Tan J, Wang Y, Yao W, Zhao Y, Li J

Purpose This study aimed to investigate the clinicopathologic features and mutational landscape of patients with hepatitis B virus (HBV)–related advanced hepatocellular carcinomas (HCC) undergoing transcatheter arterial chemoembolization (TACE). Materials and Methods From January...
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Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ

Zhou J, Liu Z, Zhang L, Hu X, Wang Z, Ni H, Wang Y, Qin J

Purpose Chronic stress and related hormones are key in cancer progression. Peroxisome proliferator-activated receptor γ (PPARγ) and its agonists was reported that inducing anti-tumor effect. However, the function of PPARγ in...
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