Korean J Infect Dis.
2000 Dec;32(6):448-451.
A Case of Overwhelming Postsplenectomy Infection following Allogeneic Hematopoietic Stem Cell Transplantation: Visualization of Diplococcus in Peripheral Blood Smear
- Affiliations
-
- 1Department of Internal Medicine, College of Medicine The Catholic University of Korea, Seoul, Korea. symonlee@cmc.cuk.ac.kr
Abstract
- Fulminant, potentially life threatening infection is a major long term risk after splenectomy. This syndrome is called overwhelming postsplenectomy infection (OPSI). OPSI has a rapidly deteriorating course that progresses to respiratory and renal failure, cardiovascular collapse, and death finally. A 40-year-old woman with chronic myelogenous leukemia was admitted through the emergency room due to abdominal discomfort and diarrhea. Three years ago she had undergone splenectomy, and had received allogeneic hematopoietic stem cell transplantation 22 months before. She suffered from chronic graft-versus-host disease and was treated with prolonged corticosteroid and cyclosporine. A diagnosis of OPSI due to Streptococcus pneumoniae was made based on peripheral blood smear and blood culture findings. Despite the early aggressive care and antibiotic treatment, her clinical course was rapidly deteriorated and died 10 hours later.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Successful engraftment after infusion of multiple low doses of CD34+ cells from a poorly matched sibling donor in a patient with severe aplastic anemia
- Erratum: Correction of Title: Impact of Day 14 Peripheral Blood Chimerism after Allogeneic Hematopoietic Stem Cell Bone Transplantation on the Treatment Outcome of Non-Malignant Disease
- A Case of Scleroderma following Autologous Peripheral Stem Cell Transplantation
- A case of pneumomediastinum combined with chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation
- The role of allogeneic hematopoietic stem cell transplantation in the four P medicine era
