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MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells

Kang YJ, Kwon YH, Jang JY, Lee JH, Lee S, Park Y, Moon HR, Chung HY, Kim ND

Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA...
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The efficacy and safety of Dendropanax morbifera leaf extract on the metabolic syndrome: a 12-week, placebo controlled, double blind, and randomized controlled trial

Jun JE, Hwang YC, Ahn KJ, Chung HY, Choung SY, Jeong IK

BACKGROUND/OBJECTIVES: The extract from Dendropanax morbifera exhibited diverse therapeutic potentials. We aimed to evaluate the efficacy and safety of D. morbifera leaf extract for improving metabolic parameters in human. SUBJECTS/METHODS: A...
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Classification, diagnosis, and treatment of vascular malformations

Lee JS, Chung HY

Background: In the 1980s, vascular anomalies were divided into two major subgroups—vascular tumors and vascular malformations—based on the functional framework. This concept has been fundamental to the management of vascular...
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Effects of Advanced Glycation End Products on Differentiation and Function of Osteoblasts and Osteoclasts

Park SY, Choi KH, Jun JE, Chung HY

Background: Risk of fragility fractures increases in patients with diabetes mellitus, independent of bone mineral density. In the present study, the effects of advanced glycation end products (AGEs) on differentiation...
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Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene

Hoang NMH, Kim S, Nguyen HD, Kim M, Kim J, Kim BC, Park D, Lee S, Yu BP, Chung HY, Kim MS

1,2-Diacetylbenzene (DAB) is a metabolite of 1,2-diethylbenzene, which is commonly used in the manufacture of plastics and gasoline. We examined the neurotoxic effects of DAB in young and old rats,...
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Clinical assessment and management of auricular arteriovenous malformation: retrospective study

Kim DG, Cho HG, Ryu JY, Lee JS, Lee SJ, Lee JM, Lee SY, Huh S, Kim JY, Chung HY

Background: Arteriovenous malformation (AVM) which is a high-blood-flow lesion with connections between arteries and veins without an intervening capillary bed, is difficult to manage. The ear is the second most...
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Signaling Role of Adipocyte Leptin in Prostate Cell Proliferation Induced by Trichomonas vaginalis

Kim JH, Han IH, Shin SJ, Park SY, Chung HY, Ryu JS

Leptin is a type of adipokine mainly produced by adipocytes and reported to be overproduced in prostate cancer. However, it is not known whether it stimulates the proliferation of prostate...
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Usefulness of meshed SurgiMend in direct-to-implant breast reconstruction

Eo PS, Lee JS, Lee JW, Choi KY, Chung HY, Cho BC, Lee J, Park HY, Yang JD

Background The use of acellular dermal matrix in implant-based breast reconstruction immediately after mastectomy has attracted attention in recent years because it yields good outcomes. Herein, we analyzed the usefulness...
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Effectiveness and Safety of Two Different Formulations of Oral Propranolol Treatment for 375 Cases of Infantile Hemangioma: A Korean Single-center Experience

Lee HJ, Ha G, Chung HY, Lee JM, Lee SY, Huh S, Kim JY, Lee SJ

  • KMID: 2514430
  • Korean J Dermatol.
  • 2021 Mar;59(3):196-205.
Background: Oral propranolol has recently been introduced as a successful treatment for infantile hemangioma (IH). Though, there are limited reports on this treatment including large number of Korean patients with IH...
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Mechanism of Lipid Accumulation through PAR2 Signaling in Diabetic Male Mice

Kim DH, Kim YR, Bang E, Ha S, Noh SG, Kim BM, Jeong SH, Jung HJ, Lee JY, Chung HY

Background: Protease-activated protein-2 (PAR2) has been reported to regulate hepatic insulin resistance condition in type 2 diabetes mice. However, the mechanism of lipid metabolism through PAR2 in obesity mice have...
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The role of peer-reviewed journals in esthetic surgery

Dhong ES, Chung HY

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Successful Microsurgical Replantation of Scalp Amputation Using Medicinal and Chemical Leech Therapy: A Case Report

Lee JH, Kim DG, Choi KY, Chung HY, Lee JS

Scalp amputation is a very rare occurrence worldwide. In particular, replantation failure may occur from venous congestion, which represents a major complication of replantation. Accordingly, this study reports on a...
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Open-Door Laminoplasty Using Lateral Mass Anchoring Screws and Nonabsorbable Sutures in Patients with Multilevel Cervical Myelopathy

Cha JR, Kim HW, Yang DG, Chung HY, Hwang IY

Background: The purpose of this study was to evaluate the clinical usefulness of open-door laminoplasty using lateral mass anchoring screws and nonabsorbable sutures (ODLLM) for multilevel cervical myelopathy. Methods: We retrospectively...
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Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells

Kim MJ, Kang YJ, Sung B, Jang JY, Ahn YR, Oh HJ, Choi H, Choi I, Im E, Moon HR, Chung HY, Kim ND

We examined the anticancer effects of a novel sirtuin inhibitor, MHY2256, on HCT116 human colorectal cancer cells to investigate its underlying molecular mechanisms. MHY2256 significantly suppressed the activity of sirtuin...
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Effect of Collagen-Enhanced Fibrin Sealant on Seroma Formation in a Rat Mastectomy Model

Kim JS, Eo PS, Lee JS, Lee JW, Choi KY, Chung HY, Cho BC, Lee J, Park HY, Yang JD

Background: Seromas are caused by leakage of lymphovascular fluid into postoperative dead space. This is the most common complication after reconstructive breast surgery. The purpose of this study is to...
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Erratum: Advantages of Distal Subtotal Gastrectomy Over Total Gastrectomy in the Quality of Life of Long-Term Gastric Cancer Survivors

Kwon OK, Yu B, Park KB, Park JY, Lee SS, Chung HY

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Correction of microtia with constriction features using a superficial temporal fascial flap combined with a rib cartilage graft

Lee JS, Kim JS, Lee JW, Choi KY, Yang JD, Chung HY, Cho BC

Background Microtia with constricted features is characterized by a short helical length of variable severity, upper antihelical or scaphal deficiency, and a downfolded upper ear. No consensus has been reached...
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Advantages of Distal Subtotal Gastrectomy over Total Gastrectomy in the Quality of Life of Long-Term Gastric Cancer Survivors

Kwon OK, Yu B, Park KB, Park JY, Lee SS, Chung HY

Purpose: This study evaluated differences and shifting patterns in the health-related quality of life (HRQoL) of 5-year gastric cancer survivors after either a distal subtotal gastrectomy (DSG) or total gastrectomy...
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Polarization of M2 Macrophages by Interaction between Prostate Cancer Cells Treated with Trichomonas vaginalis and Adipocytes

Chung HY, Kim JH, Han IH, Ryu JS

Trichomonas vaginalis causes inflammation of the prostate and has been detected in tissues of prostate cancers (PCa), prostatitis and benign prostatic hyperplasia. Obesity is a risk factor for PCa and...
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Information-Stressors and Cancer Patients’ Quality of Life: Responses to Deviant Information-Stressors Due to Pre-Postoperative Stage Discordance

Lee SS, Chung HY, Kwon OK

This study assessed preoperative quality of life (QoL) of gastric cancer patients exposed to inconsistent illness information by pre-post-operative stage discordance. The impact of information-stressors on patients’ QoL was investigated...
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