Korean J Clin Pathol.  2001 Oct;21(5):327-330.

Two Cases of Philadelphia Chromosome-negative Essential Thrombocythemia Manifested bcr-abl Gene Rearrangement

Affiliations
  • 1Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea.

Abstract

Discrepant results have been reported in terms of detecting bcr-abl transcripts in patients with essential thrombocythemia that are Philadelphia (Ph) chromosome-negative. We present two cases of Ph chromosome-negative essential thrombocythemia in whom bcr-abl gene rearrangement was detected. In the diagnosis of both cases, they lacked the splenomegaly, anemia and basophilia, and had high platelet counts (948X10(3)/L and 1,329X10(3)/microL, respectively) and normal leukocyte alkaline phosphatase (LAP) scores on admission without any evidence of inflammation, infection, or therapy. They lacked the Philadelphia chromosome characteristic of classical chronic myelogenous leukemia (CML) and had b3a2 transcripts.

Keyword

Ph chromosome-negative essential thrombocythemia; bcr-abl rearrangement; b3a2 transcripts

MeSH Terms

Alkaline Phosphatase
Anemia
Diagnosis
Gene Rearrangement*
Humans
Hydrogen-Ion Concentration
Inflammation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukocytes
Philadelphia Chromosome
Platelet Count
Splenomegaly
Thrombocythemia, Essential*
Alkaline Phosphatase
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