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Characterization of clonal immunoglobulin heavy (IGH) V-D-J gene rearrangements and the complementarity-determining region in South Indian patients with precursor B-cell acute lymphoblastic leukemia

Sudhakar N, Rajkumar T, Rajalekshmy KR, Nancy NK

BACKGROUND: This study characterized clonal IG heavy V-D-J (IGH) gene rearrangements in South Indian patients with precursor B-cell acute lymphoblastic leukemia (precursor B-ALL) and identified age-related predominance in VDJ rearrangements. METHODS:...
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Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group

Kim H, Shim HS, Kim L, Kim TJ, Kwon KY, Lee GK, Chung JH, Korean Cardiopulmonary Pathology Study Group

  • KMID: 1875751
  • Korean J Pathol.
  • 2014 Feb;48(1):1-9.
Rearrangement of anaplastic lymphoma kinase (ALK) gene is the best predictor of response to crizotinib, an ALK tyrosine kinase inhibitor. However, the prevalence of the ALK fusion is low, so...
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Polymerase Chain Reaction and Sequencing of Immunoglobulin Heavy Chain Gene Rearrangement in Formalin Fixed, Paraffin-embedded Tissue of Patients with B Cell Lymphoma

Cho SR, Park IJ, Lee MS, Kim EK, Lee WG, Han JH, Park JE, Park JS, Kim HC

BACKGROUND: Immunoglobulin heavy chain (IgH) gene rearrangement has been known to be a useful marker for determining the clonality as well as detecting minimal residual disease in B cell malignancies....
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Comparison of the Rate of Detection of Immunoglobulin Heavy Chain Gene Rearrangement by Fluoresecence In Situ Hybridization Probes in Multiple Myeloma

Chung HY, See CJ, Choi JE, Min HJ, Cho HI, Lee DS

BACKGROUND: Immunoglobulin heavy chain (IgH) gene rearrangement, which is frequently observed in multiple myeloma, can now be detected easily by using a fluorescence in situ hybridization (FISH) method. The aim...
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Diagnostic Utility of Polymerase Chain Reaction-Based Clonality Analysis for Immunoglobulin Heavy Chain Gene and T-cell Receptor Gamma Chain Gene Rearrangement in Lymphoid Neoplasms

Cho EY, Ko YH, Kim DS, Han JJ, Ree HJ

  • KMID: 2275585
  • Korean J Pathol.
  • 2001 Dec;35(6):461-469.
BACKGROUND: The clonality of lymphoid infiltrates determined by polymerase chain reaction (PCR) for immunoglobulin heavy chain (IgH) or T cell receptor (TCR) genes is not only useful in confirming the...
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Two Cases of Philadelphia Chromosome-negative Essential Thrombocythemia Manifested bcr-abl Gene Rearrangement

Jung TK, Lee NY, Suh JS

  • KMID: 2146100
  • Korean J Clin Pathol.
  • 2001 Oct;21(5):327-330.
Discrepant results have been reported in terms of detecting bcr-abl transcripts in patients with essential thrombocythemia that are Philadelphia (Ph) chromosome-negative. We present two cases of Ph chromosome-negative essential thrombocythemia...
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Polymerase Chain Reaction and Heteroduplex Analysis Based Detection of Clonal T Cell Receptor Gamma Gene Rearrangements in Paraffin-embedded Tissues of Cutaneous T Cell Proliferative Diseases

Yeo UC, Park K, Ko YH, Lee ES, Han KH, Kim CW, Cho KH

BACKGROUND: Recently, the molecular pathologic investigation for clonality in lymphomas has been introduced and has gained a role in the diagnosis of lymphomas. In fact, the clonality test using TCRGR...
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Simultaneous Reverse Transcription-Polymerase Chain Reaction for Detection of 7 Gene Rearrangements in Acute Leukemia

Kim KH, Han JY

  • KMID: 2300484
  • Korean J Clin Pathol.
  • 2001 Feb;21(1):24-33.
Background: The diagnosis of acute leukemia is multidisciplinary with histology, immunology, and cytogenetics. Among these, cytogenetics is important for diagnosis and analysis of prognosis and some of the chromosomal abnormalities...
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A Case of Chronic Myelogenous Leukemia Manifested bcr-abl Gene Rearrangement in Pleural Effusion

Kang MS, Choi JW, Pai SH

  • KMID: 2089525
  • Korean J Clin Pathol.
  • 1998 Sep;18(3):315-320.
Chronic myelogenous leukemia (CML) has been reported to show extra-medullary involvement in 10% of cases and affect mostly lymph nodes and spleen. Extensive pleura involvement of leukemic cells is very...
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A Case of T-cell Primary Pulmonary LymphomaDiagnosed by TCRgamma gene rearrangement

Choi YM, Kim SJ, Kwon SS, Kim YK, Kim KH, Moon HS, Park SH, Song JS

No abstract available.
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Gene rearrangement of specific exons of immunoglobulin heavy chain joining region in B- lymphoid leukemias

Park CJ, Cho HC, Uhmacher J

  • KMID: 1688373
  • Korean J Hematol.
  • 1993 Nov;28(2):307-312.
No abstract available.
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detection of BCR-ABL gene rearrangement by use of the polymerase chain reaction in chronic myeloid leukemia

Kim JS, Kim JH, Uh WG, Kim SH, Kim SY, Yoon HJ, Cho KS

  • KMID: 1688309
  • Korean J Hematol.
  • 1993 May;28(1):71-80.
No abstract available.
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Antigen receptor gene rearrangement patterns of lymphoproliferative diseases

Kim SH, Kim SY, Yoon HJ, Cho KS, Kim SI

  • KMID: 1697989
  • Korean J Intern Med.
  • 1991 Oct;41(4):524-541.
No abstract available.
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