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Successful Treatment of a Korean Infant with Giant Cell Hepatitis with Autoimmune Hemolytic Anemia Using Rituximab

Kim YH, Kim JW, Lee EJ, Kang GH, Kang HJ, Moon JS, Ko JS

Giant cell hepatitis with autoimmune hemolytic anemia (AHA) is a rare disease of infancy characterized by the presence of both Coombs-positive hemolytic anemia and progressive liver disease with giant cell...
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Therapeutic Plasma Exchange in a Patient with Hemophagocytic Lymphohistiocytosis

Roh J, Kim S, Nah H, Lee K, Kim HO

A 22-year old female patient with systemic lupus erythematosus presenting microangiopathic hemolytic anemia was treated with therapeutic plasma exchange 23 times. The patient's condition and laboratory findings (aspartate aminotransferase, alanine...
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Efficacy of Annexin A1 Immunostaining in Bone Marrow for the Diagnosis of Hairy Cell Leukemia

Park CH, Kim HY, Shin SY, Kim HJ, Jung CW, Kim JW, Kim SH

Splenic B-cell lymphomas (SBCLs) show characteristically pronounced splenomegaly without significant lymphadenopathy. Distinguishing hairy cell leukemia (HCL) from other SBCLs (splenic marginal zone lymphoma [SMZL], variant HCL [v-HCL], and splenic diffuse...
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Long-Term Efficacy and Safety of Partial Splenic Embolization in Hepatocellular Carcinoma Patients with Thrombocytopenia Who Underwent Transarterial Chemoembolization

Kim NH, Kim HJ, Cho YK, Hong HP, Kim BI

BACKGROUND: Performing transarterial chemoembolization (TACE) is difficult with the occurrence of thrombocytopenia in cirrhotic patients with hepatocellular carcinoma (HCC). We aimed to evaluate the long-term efficacy and safety of partial...
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Status of common parasitic diseases in Korea in 2019

Huh S

This study aimed to determine the status of common parasitic disease in Korea in 2019. Twelve parasitic diseases were selected: toxocariasis, anisakiasis, paragonimiasis, sparganosis, cysticercosis, toxoplasmosis, clonorchiasis, enterobiasis, trichuriasis, trichomoniasis,...
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Human Embryonic Stem Cells-Derived Mesenchymal Stem Cells Reduce the Symptom of Psoriasis in Imiquimod-Induced Skin Model

Kim CH, Lim CY, Lee JH, Kim KC, Ahn JY, Lee EJ

BACKGROUND: Mesenchymal stem cells (MSCs) can be used for a wide range of therapeutic applications because of not only their differentiation potential but also their ability to secrete bioactive factors....
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CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice

Kim JI, Park JS, Kwak J, Lim HJ, Ryu SK, Kwon E, Han KM, Nam KT, Lee HW, Kang BC

CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein α (SIRPα) on macrophages and thereby inhibits...
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Role of CT in Differentiating Malignant Focal Splenic Lesions

Jang S, Kim JH, Hur BY, Ahn SJ, Joo I, Kim MJ, Han JK

OBJECTIVE: The purpose of this study was to asses the CT findings and clinical features differentiating malignant from benign focal splenic lesions. MATERIALS AND METHODS: Among 673 patients with splenectomy, we...
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Cogan Syndrome Accompanied with Meningitis

Kim HK, Oh EH, Jung NY, Choi JH

Cogan syndrome is a rare inflammatory disease characterized by intraocular inflammation and vestibulo-auditory dysfunction. The exact etiology of Cogan syndrome is still unknown, but is currently thought to be an...
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Massive splenomegaly: flow cytometry as a diagnostic tool for systemic mastocytosis

Rastogi L, Dass J, Dhingra G, Gupta N, Kotwal J

No abstract available.
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Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer

Kang J, Park JS, Ahn SG, Lim JH, Baik SH, Yoon DS, Lee KY, Jeong J

PURPOSE: This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer. METHODS: This retrospective study...
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Recent advances in the diagnosis and management of primary myelofibrosis

Takenaka K, Shimoda K, Akashi K

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) in which dysregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathways is the major pathogenic mechanism. Most patients...
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Two Korean Cases of Hereditary Spherocytosis Caused by Mutations in SLC4A1

Cho H, Lee JW, Chung NG, Lee SE, Jang W, Kim M, Han K, Kim Y

Hereditary spherocytosis (HS) is caused by mutations in the SPTA1, SPTB, ANK1, SLC4A1, and EPB42 genes, all of which encode erythrocyte membrane proteins. Mutations in SLC4A1, which encodes band 3...
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A Sporadic Case of Epstein Syndrome: A Rare Cause of Refractory Thrombocytopenia

Song KM, Song H, Jeong DH, Lee J, Noh SM, Lee BH, Lee KH

A 37-year-old female presented to our hospital with a history of bleeding episodes (excessive bleeding after tooth extraction, gum bleeding, easy bruising, and excessive menstruation) and severe thrombocytopenia (2,000/µL). She...
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A Case of Recurrent Steroid-dependent Kikuchi-Fujimoto Disease Successfully Treated with Hydroxychloroquine

Jang KM, Lee JM

Kikuchi-Fujimoto disease (KFD) is known as a self-limiting disease. The most common symptoms include fever, cervical lymphadenopathy, and pain, but nonspecific symptoms such as joint pain, nausea, chills, diaphoresis, and...
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Schistosoma mansoni Infection and Its Related Morbidity among Adults Living in Selected Villages of Mara Region, North-Western Tanzania: A Cross-Sectional Exploratory Study

Mazigo HD, Nuwaha F, Dunne DW, Kaatano GM, Angelo T, Kepha S, Kinung’hi SM

Schistosoma mansoni is highly endemic in Tanzania and affects all age groups at different degrees. However, its control approach does not include adult individuals who are equally at risk and...
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Laparoscopic Splenectomy for a Patient with Splenomegaly and Hypersplenism due to Idiopathic Portal Hypertension

Yang K, Yun SP, Kim JH, Kim DH, Kim HS, Seo HI

Idiopathic portal hypertension (IPH) is a rare disorder which is clinically characterized by portal hypertension, splenomegaly, hypersplenism and the absence of liver cirrhosis. Patients with IPH have massive splenomegaly leading...
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Hairy cell leukemia: a case report of atypical presentation without splenomegaly

Alfaraj M, Alsaeed H

No abstract available.
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Ultrasound-Guided Percutaneous Core Needle Biopsy of Splenic Lesions

Park S, Shin YM, Won HJ, Kim PN, Lee MG

PURPOSE: To evaluate the safety and efficacy of ultrasound-guided percutaneous core needle biopsy of splenic lesions. MATERIALS AND METHODS: This retrospective study included 30 patients who underwent percutaneous core needle biopsy...
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Radiographic features of plasma cell leukemia in the maxilla: A case report

Wong P, Kashtwari , Nair MK

Plasma cell leukemia (PCL) is an aggressive form of multiple myeloma where there is hematogenous spread of abnormal plasma cells into the periphery. This is opposed to multiple myeloma, where...
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