J Korean Soc Magn Reson Med.  2013 Dec;17(4):294-307. 10.13104/jksmrm.2013.17.4.294.

Investigation of the Correlation between Seoul Neuropsychological Screening Battery Scores and the Gray Matter Volume after Correction of Covariates of the Age, Gender, and Genotypes in Patients with AD and MCI

• Lee SY
• Yoon SY
• Kim MJ
• Rhee HY
• Ryu CW
• Jahng GH

• KMID: 2144331
• DOI: http://doi.org/10.13104/jksmrm.2013.17.4.294

Abstract

PURPOSE
To investigate the correlations between Seoul Neuropsychological Screening Battery (SNSB) scores and the gray matter volumes (GMV) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and cognitively normal (CN) elderly subjects with correcting the genotypes.
MATERIALS AND METHODS
Total 75 subjects were enrolled with 25 subjects for each group. The apolipoprotein E (APOE) epsilon genotypes, SNSB scores, and the 3D T1-weighted images were obtained from all subjects. Correlations between SNSB scores and GMV were investigated with the multiple regression method for each subject group using both voxel-based and region-of-interest-based analyses with covariates of age, gender, and the genotype.
RESULTS
In the AD group, Rey Complex Figure Test (RCFT) delayed recall scores were positively correlated with GMV. In the MCI group, Seoul Verbal Learning Test (SVLT) scores were positively correlated with GMV. In the CN group, GMV negatively correlated with Boston Naming Test (K-BNT) scores and Mini-Mental State Examimation (K-MMSE) scores, but positively correlated with RCFT scores.
CONCLUSION
When we used covariates of age, gender, and the genotype, we found statistically significant correlations between some SNSB scores and GMV at some brain regions. It may be necessary to further investigate a longitudinal study to understand the correlation.

Keyword

SNSB; brain gray matter volume; genotype covariate; Alzheimer's type dementia; multiple regressions

MeSH Terms

Aged
Alzheimer Disease
Apolipoproteins
Brain
Genotype*
Humans
Mass Screening*
Methods
Mild Cognitive Impairment
Seoul*
Verbal Learning
Apolipoproteins

Figure

• 

  Fig. 1 Results of the voxel-based positive correlations between gray matter volume and Rey complex figure test (RCFT) delayed recall scores in Alzheimer's disease (AD) patients (a) or Seoul verbal learning test (SVLT) scores in mild cognitive impairment (MCI) patients (b).

• 

  Fig. 2 Results of the voxel-based correlations between gray matter volume and Seoul Neuropsychological Screening Battery (SNSB) scores in the elderly cognitive normal (CN) subjects. a. The negative correlation (blue color) between gray matter volume and Korean version of Boston naming test (K-BNT) scores. b. The negative correlation (blue color) between gray matter volume and Korean version of mini-mental state examination (K-MMSE) scores c. The positive correlation (red color) between gray matter volume and Rey complex figure test (RCFT) scores

• 

  Fig. 3 Results of the region-of-interest-based correlations between gray matter volume and Seoul Neuropsychological Screening Battery (SNSB) scores. a. The positive correlation with the Rey complex figure test (RCFT) delayed recall scores in Alzheimer's disease (AD) patients. b. The positive correlation with the Seoul verbal learning test (SVLT) scores in mild cognitive impairment (MCI) patients. c. The negative correlation with the Korean version of Boston naming test (K-BNT) scores in the elderly cognitive normal (CN) subjects. d. The negative correlation with the Korean version of mini-mental state examination (K-MMSE) scores in CN. subjects e. The positive correlation with the RCFT scores in CN subjects.

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