Study on Hepatic Damage by Adriamycin- and Cisplatin-Lipiodol Emulsions Injected into Proper Hepatic Artery of Rabbits

Cho, Mong; Moon, Tae Yong; Lee, Suck Hong; Sim, Mun Sup; Kim, Chang Won; Kim, Suck

Abstract

BACKGROUND AND AIMS: The present study was performed to evaluate chronic hepatic damage induced by adriamycin-lipiodol and cisplatin-lipiodol emulsions infused into the proper hepatic artery of rabbits.
METHODS
Twenty- four rabbits were divided into seven groups. Each group had their proper hepatic arery infused by normal saline 1.58 ml/kg, lipiodol, adriamycin-lipiodol, cisplatin- lipiodol 0.15 and 0.30 ml/kg, respectively. Two months after infusion of chemoembolic materials, we evaluated body and liver weight and hepatic parenchymal damage.
RESULTS
After two months, the growth rates of the rabbit and the liver in two ernulsions infusion groups were lower than those in the normal saline infusion group. Those in the adriamycin-lipiodol emulsion infusion group were lower than those in the cisplatin-lipiodol emulsion infusion group. The histologicfindings of chronic hepatic damage after transhepatic arterial chemoembolic material infusions were lobular and periportal inflammatory cell infiltration and hepatic cell necrosis. Those findings were more serious in the two emulsion infusion groups than in the normal saline infusion group.
CONCLUSIONS
The transhepatic arterial chemoembolic material infusion has induced irreversible damage with inflammatory cell infiltration in the rabbit liver. Adriamycin-lipiodol emulsion has induced more serious damage in the liver than cisplatin-lipiodol emulsion when used as transhepatic arterial chemoembolic materials.