Korean J Hematol.  2002 Nov;37(4):265-269.

Glutathione S-Transferase (GST) Gene Deletions in Korean Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome

• Woo HY
• Lee KA
• Hong YJ
• Park HS
• Kim SH

Abstract

BACKGROUND: There have been many studies on the association between the glutathione S- transferase (GST) genotype and the susceptibility to acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) and the results are still controversial. We tested whether the homozygous null genotype of GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes influences the risk for MDS and AML.
METHODS
We analyzed bone marrow DNA samples from 54 patients with AML or MDS (14 de novo AML, 7 secondary AML, and 33 MDS) and peripheral blood DNA samples from 75 cancer-free controls. The GSTM1 and GSTT1 genotypes were analyzed by multiplex polymerase chain reaction (PCR).
RESULTS
The frequencies of GSTM1 null and GSTT1 null were not significantly increased in AML/MDS cases compared with those in controls.
CONCLUSION
Our data suggest that GSTM1 and GSTT1 null genotypes may not predispose to AML/MDS in Korean population.

Keyword

Glutathione S-transferase (GST) gene deletion; Acute myeoloid leukemia; Myelodysplastic syndrome

MeSH Terms

Bone Marrow
DNA
Gene Deletion*
Genotype
Glutathione Transferase*
Glutathione*
Humans
Leukemia, Myeloid, Acute*
Multiplex Polymerase Chain Reaction
Myelodysplastic Syndromes*
Transferases
DNA
Glutathione
Glutathione Transferase
Transferases