J Korean Soc Plast Reconstr Surg.  2009 Jul;36(4):372-379.

Comparative Efficacy of Silver Containing Dressing Materials to Staphylococcus aureus and Pseudomonas aeruginosa on Infected Full Thickness Skin Wound in the Rat

Affiliations
  • 1Department of Plastic and Reconstructive Surgery, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea. joaljh@eulji.ac.kr
  • 2Department of Pathology, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea.
  • 3Department of Laboratory Medicine, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea.

Abstract

PURPOSE
The purpose of this study is to compare the effect of antibacterial activities and wound healing effect of silver containing dressings such as Staphylococcus aureus and Pseudomonas aeruginosa with against Betadine.
METHODS
One full thickness skin defects in rats(n=72) were developed on the back and were given rise to infection with S. aureus(n=36) and P. aeruginosa(n= 36). The 72 mice were divided into 6 groups:Acticoat(R), Aquacel(R)-Ag, Medifoam silver(R), Polymen silver(R), Ilvadon(R) and Betadine(control group) dressing groups. Five silver containing dressings and Betadine were assesed on infected wound. Measurement of wound size change, bacterial colonies count and histologic findings was applied. Antibacterial activity was analyzed with bacterial restricted zone in Mueller Hinton agar.
RESULTS
For S. aureus, wound size was more decreased in all treated groups compared to betadine group, however Ilvadon(R)-treated wound was less decreased on P. aeruginosa. In histologic findings, experimental group showed more effective findings than others on S. aureus, however on P. aeruginosa, which was shown similar. Acticoat(R) was best effective in wound healing against both S. aureus and P. aeruginosa. The bacterial colonies count was increased in all treated groups except Acticoat(R) compared to the control group on S. aureus, which was decreased in Acticoat(R) and Ilvadon(R) group on P. aeruginosa. There were not statistical differences. The restricted zone was shown in Mueller-Hinton agar of all groups except Medifoam silver(R) group on S. aureus, which was shown in all groups on P. aeruginosa. There were statistical differences.
CONCLUSION
This study suggests that silver containing dressings may not have better potential than Betadine in assisting management of wounds at risk of infection on S. aureus and P. aeruginosa. However, which have better antibacterial activity on S. aureus and P. aeruginosa.

Keyword

Staphylococcus aureus; Pseudomonas aeruginosa; Silver dressing; Skin defect; Infection

MeSH Terms

Agar
Animals
Bandages
Equidae
Mice
Povidone-Iodine
Pseudomonas
Pseudomonas aeruginosa
Rats
Silver
Skin
Staphylococcus
Staphylococcus aureus
Wound Healing
Agar
Povidone-Iodine
Silver
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