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Comparison of In Vivo Pharmacokinetics and Pharmacodynamics of Vancomycin Products Available in Korea

Kim HK, Choi SM, Kang G, Park KH, Lee DG, Park WB, Rhee SJ, Lee S, Jung SI, Jang HC

PURPOSE: Few studies have been investigated the in vivo efficacy of generic vancomycin products available outside of the United States. In this study, we aimed to compare the in vivo...
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Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis

Yin H, Wang S, Gu C

BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals. OBJECTIVE: Since the limitation of dataset associated with human severe AD,...
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Season and Temperature Effects on Bloodstream Infection Incidence in a Korean Tertiary Referral Hospital

Sohn YS, Byun JH, Kim YA, Shin DC, Lee K

BACKGROUND: The weather has well-documented effects on infectious disease and reports suggest that summer peaks in the incidences of gram-negative bacterial infections among hospitalized patients. We evaluated how season and...
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Contamination Rate of Burnt Necrotic Tissue after Electrocoagulation in Total Knee Arthroplasty

Rattanaprichavej P, Laoruengthana A, Galassi M, Weerakul S, Rasamimongkol S

BACKGROUND: Periprosthetic joint infection (PJI) is one of the commonly found catastrophic complications after total knee arthroplasty (TKA). Preoperative antibiotic prophylaxis, proper skin cleansing, shortened operative time, and sterility of...
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Culture-Positive Spontaneous Ascitic Infection in Patients with Acute Decompensated Cirrhosis: Multidrug-Resistant Pathogens and Antibiotic Strategies

Liu J, Gao Y, Wang X, Qian Z, Chen J, Huang Y, Meng Z, Lu X, Deng G, Liu F, Zhang Z, Li H, Zheng X

PURPOSE: This study investigated multidrug-resistant (MDR) pathogens and antibiotic strategies of culture-positive spontaneous ascitic infection (SAI) in patients with acute decompensated cirrhosis. MATERIALS AND METHODS: We retrospectively analyzed 432 acute decompensated...
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Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients

Thompson K, Rainer BM, Antonescu , Florea L, Mongodin E, Kang S, Chien AL

BACKGROUND: Associations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics. OBJECTIVE: We performed a case-control study...
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Complete genome sequence of a methicillin-resistant Staphylococcus schleiferi strain from canine otitis externa in Korea

Lee GY, Yang SJ

The increase in canine skin and soft tissue infections, such as pyoderma and otitis, caused by Staphylococcus schleiferi strains, is of significant zoonotic concern. In this study, we report the...
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Livestock-associated methicillin-resistant Staphylococcus aureus in Korea: antimicrobial resistance and molecular characteristics of LA-MRSA strains isolated from pigs, pig farmers, and farm environment

Back SH, Eom HS, Lee HH, Lee GY, Park KT, Yang SJ

The emergence of livestock-associated (LA)-methicillin-resistant Staphylococcus aureus (MRSA) in livestock animal has become a significant zoonotic concern. In the present study, we investigated nationwide prevalence of LA-MRSA across pork production...
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The Use of Inappropriate Antibiotics in Patients Admitted to Intensive Care Units with Nursing Home–Acquired Pneumonia at a Korean Teaching Hospital

Kim DH, Kim HJ, Koo HW, Bae W, Park SH, Koo HK, Park HK, Lee SS, Kang HK

BACKGROUND: Use of appropriate antibiotics for the treatment of pneumonia is integral in patients admitted to intensive care units (ICUs). Although it is recommended that empirical treatment regimens should be...
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Comparison of 16S Ribosomal RNA Targeted Sequencing and Culture for Bacterial Identification in Normally Sterile Body Fluid Samples: Report of a 10-Year Clinical Laboratory Review

Yoo IY, Kang OK, Lee MK, Kim YJ, Cho SY, Huh K, Kang CI, Chung DR, Peck KR, Huh HJ, Lee NY

As 16S ribosomal RNA (rRNA)-targeted sequencing can detect DNA from non-viable bacteria, it can be used to identify pathogens from clinical samples even in patients pretreated with antibiotics. We compared...
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Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus in Korea: High Rate of False Resistance to Linezolid by the VITEK 2 System

Yoo IY, Kang OK, Shim HJ, Huh HJ, Lee NY

As various linezolid resistance mechanisms have been identified in methicillin-resistant Staphylococcus aureus (MRSA), we investigated the molecular characteristics of MRSA with elevated linezolid minimum inhibitory concentrations (MICs), using the VITEK...
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Report of the Korean Association of External Quality Assessment Service on Clinical Bacteriology and Mycology (2016)

Kim JS, Lee HS

Annual proficiency surveys were conducted thrice in 2016 as a part of the Clinical Microbiology Program of the Korean Association of External Quality Assessment Service. This program covers the fields...
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Clinical Review of Staphylococcal Scalded Skin Syndrome in a Single Institution for 18 Years, 2001–2018

Lee SJ, Lee DW

Staphylococcal scalded skin syndrome (SSSS) is a disease caused by exfoliative toxin. The purpose of this study is to analyze clinical features, laboratory findings and treatment outcome of patients who...
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Clinical Review of Staphylococcal Scalded Skin Syndrome in a Single Institution for 18 Years, 2001–2018

Lee SJ, Lee DW

Staphylococcal scalded skin syndrome (SSSS) is a disease caused by exfoliative toxin. The purpose of this study is to analyze clinical features, laboratory findings and treatment outcome of patients who...
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Clinical Review of Staphylococcal Scalded Skin Syndrome in a Single Institution for 18 Years, 2001–2018

Lee SJ, Lee DW

Staphylococcal scalded skin syndrome (SSSS) is a disease caused by exfoliative toxin. The purpose of this study is to analyze clinical features, laboratory findings and treatment outcome of patients who...
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The Activation of PPAR-α and Wnt/β-catenin by Luffa cylindrica Supercritical Carbon Dioxide Extract

Kim B

Luffa cylindrica (LC) is a very fast-growing climber and its fruit have been considered as agricultural wastes. We conducted to check the comparative qualities of ethanol solvent extraction (LCE) and...
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The Characteristics of Staphylococcal Scalded Skin Syndrome in Atopic Dermatitis

Jung WJ, Kim SW, Hwang YH

OBJECTIVES: Staphylococcal scalded skin syndrome (4S), a blistering dermatosis caused by exfoliative toxins from Staphylococcus aureus, occurs frequently in patients with atopic dermatitis (AD). However, association between 4S and AD...
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Antibiotic sensitivity and resistance of bacteria from odontogenic maxillofacial abscesses

Kang SH, Kim MK

OBJECTIVES: This study investigated the types and antibiotic sensitivity of bacteria in odontogenic abscesses. MATERIALS AND METHODS: Pus specimens from 1,772 patients were collected from affected areas during incision and drainage,...
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The Cefazolin Inoculum Effect and the Presence of type A blaZ Gene according to agr Genotype in Methicillin-Susceptible Staphylococcus aureus Bacteremia

Lee SO, Lee S, Park S, Lee JE, Lee SH

BACKGROUND: Recent data suggests the inoculum effect of methicillin-susceptible Staphylococcus aureus (MSSA) against beta-lactam antibiotics and their association with functionality or genotypic variation of agr locus. METHODS: MSSA blood isolates were...
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Molecular Epidemiologic Study of a Methicillin-resistant Staphylococcus aureus Outbreak at a Newborn Nursery and Neonatal Intensive Care Unit

Kang HM, Park KC, Lee KY, Park J, Park SH, Lee DG, Kim JH

PURPOSE: This study aimed to investigate the molecular epidemiology of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak at a newborn nursery and neonatal intensive care unit (NICU). METHODS: During the outbreak, from...
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