J Korean Ophthalmol Soc.  1999 Aug;40(8):2074-2086.

The Trend of Species and Microbial Susceptibility of Bacteria Isolated from the Anophthalmic Socket and Fellow Normal Conjunctiva

Affiliations
  • 1Department of Ophthalmology, Korea Veterans Hospital, Seoul, Korea.

Abstract

In 189 consecutive non-inflamed anophthalmic patients wearing uniocular prosthesis, the conjunctival flora was evaluated and compared to that of the opposite healthy eye. And this results were compared with that of department of clinical pathology studied from January 1997 to July 1998. The incidence of bacterial isolation on the anophthalmic side (63.5%) was significantly higher than that on the healthy side (28.0%). Especially, the incidence of potential pathogenic bacterial isolation. (S.aureus, streptococci spp. and gram-negative bacilli grouped together) on the anophthalmic side (42.3%) was very significantly higher (p<0.001) than that on the healthy side (6.9%).The antimicrobial susceptibility to ciprofloxacin was high (>90%) in all bacterial isolate from the both anophthalmic socket and fellow normal conjunctiva. The bacteria isolated from the anophthalmic socket and fellow normal conjunctiva were similarly sensitive to vancomycin,clindamycin, gentamicin, imipenem, tobramycin, amikacin, netilmicin, colistin and were resistant to penicillin, ampicillin and tetracycline. No significant difference in the anophthalmic conjunctival flora between our study and the previous report but the antimicrobial susceptibility to clindamycin in coagulase-negative staphlyococcus (CNS) and S.aureus from the anophthalmic socket is higher than that of the previous report. The antimicrobial susceptibility to erythromycin in gram-positive bacteria except coagulase-negative staphlyococcus (CNS) and S.aureus from the anophthalmic socket is lower than that of the previous report. The species isolated from our study were more sensitive to the majority of antimicrobial agents than that of the microbial laboratory report. But,the antimicrobial susceptibilities of our study to chloramphenicol and colistin were very significantly lower than that of the microbial laboratory report (p<0.001).

Keyword

Anophthalmic conjunctiva; Antimicrobial susceptibility; Bacterial flora; Ocular prosthesis

MeSH Terms

Amikacin
Ampicillin
Anti-Infective Agents
Bacteria*
Chloramphenicol
Ciprofloxacin
Clindamycin
Colistin
Conjunctiva*
Erythromycin
Eye, Artificial
Gentamicins
Gram-Positive Bacteria
Humans
Imipenem
Incidence
Netilmicin
Pathology, Clinical
Penicillins
Prostheses and Implants
Tetracycline
Tobramycin
Amikacin
Ampicillin
Anti-Infective Agents
Chloramphenicol
Ciprofloxacin
Clindamycin
Colistin
Erythromycin
Gentamicins
Imipenem
Netilmicin
Penicillins
Tetracycline
Tobramycin
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