J Korean Pediatr Soc.  1980 Sep;23(9):717-723.

Renal Changes in Henoch-Schonlein Purpura with Normal Renal Function

• Lee C
• Kim PK
• Yun DJ
• Choi IJ

Abstract

Henoch-Schonlenin purpura is one of the most common cause of purpura of children in Korea at present time, but well summarized report about the incidence in Korea is not submitted yet. Renal involvemnet in Henoch-Schonlein purpura nephritis is one of the important cause of end stage kidney disease in chidhood, accounting for about 15% of children who are on dialysis programs in the United Kingdom. The proportion of patients reported to have a renal involvement varies from 20% to 85%, and also the natural history from the beginning of the disease is still not well established. For these reasons, this study aims on the preliminary report on the renal changes, clinically, pathologically and immunopathologically, in three patientsof Henoch-Schonlein purpura with normal renal function. Renal biopsies show normal to minimal endocapillary cell proliferation, with a few neutrophil participation in the glomerular capillary. Mesangial matrix is partially widened in a case. Immunopathological study shows uniformly patchy focal to diffuse, spotty deposits of IgA in the mesangium, but IgG, C3, fibrinogen and IgM are lesser in degree. A case with recurrent attacks shows a focal segmental involvement by IgG, which can be considered presumably due to recurrent intermittent antigenic challenge.

MeSH Terms

Biopsy
Capillaries
Cell Proliferation
Child
Dialysis
Fibrinogen
Great Britain
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Incidence
Kidney Failure, Chronic
Korea
Natural History
Nephritis
Neutrophils
Purpura
Purpura, Schoenlein-Henoch*
Fibrinogen
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M