J Korean Radiol Soc.
1997 Jun;36(6):921-932.
Diffusion- and T2-Weighted MR Imaging of Lipiodol Induced Cerebral Infarcts in Cat: Early Findings in the Findings in the First 3 Hours
- Affiliations
-
- 1Department of Diagnostic Radiology, Ulsan University College of Medicine.
- 2Department of Pathology, Seoul City Boramae Hospital.
- 3Medical Electronics Team, Samsung Biomedical Research Institute.
- 4Department of Medical Electronics, Korea University.
- 5Department of Preventive Medicine, Ulsan University Collge of Medicine.
- 6Department of Anesthesiology, Ulsan University College of Medicine.
- 7Department of Radiology, Seoul National University Hospital.
Abstract
- PURPOSE
This study was designed to evaluate early parenchymal changes of acute cerebral ischemia / infarct by using T2-weighted, diffusion-weighted, and calculated apparent diffusion coefficient (ADC) MR imaging.
MATERIALS AND METHODS
The brain MR images were successfully obtained 30, 60, 90, 120, 150 and 180 minutes after intraarterial administration of Lipiodol (0.4 - 0.6 ml) into the common carotid artery in 10 of 11 cats (91%). T2-and diffusion-weighted images and ADC were analyzed and compared with histopathologic findings.
RESULTS
High signal intensity on T2-weighted and diffusion-weighted images was found in one cerebral hemisphere 30 minutes after Lipiodol injection, which tended to increase with time until 3 hours. Subcortical white matter showed higher signal intensity than cortical gray matter since 30 minutes after embolization. ADC images showed decreased signal intensity in the embolized hemisphere, which tended to decrease until 3 hours. Microscopic findings of the area corresponding to the abnormal signal intensity on MR images revealed varying degrees of edema in the gray and white matters involved.
CONCLUSION
It is suggested that Lipiodol can be used as a good embolic agent causing early ischemic changes in experimental models. In addition to T2-weighted images, diffusion-weighted and ADC images can provide the further informations in the evaluation of the early parenchymal changes of cerebral infarct.
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