Korean J Anat.  2004 Oct;37(5):491-498.

Expression of Preadipocyte Factor-1 (Pref-1) and Vitamin D3 Up-regulated Protein 1 (VDUP1) Genes in Rat Adrenal Gland following Chronic Immobilization Stress

• Lee YK
• Park JW
• Song SS
• Yang Y
• Lee KS
• Lee YH

Abstract

Preadipocyte factor-1 (Pref-1) is expressed in the neuroendocrine organs such as the pituitary gland, the adrenal gland, the pancreas, the testis, etc. Vitamin D3 up-regulated protein 1(VDUP1) gene is known to be a novel member of early response genes as an oxidative stress mediator. The aim of the present study was to investigate whether Pref-1 and VDUP1 is involved in stress response in the adrenal gland following chronic immobilization stress. In situ hybridization for Pref-1 and VDUP1 genes (Pref-1 and VDUP1) was performed in the rat adrenal glands following immobilization stress, 2 hr once daily for 7 days. In situ hybridization analysis revealed that Pref-1 expression was up-regulated in rat adrenal medulla following chronic immobilization stress. However, Pref-1 was down-regulated in the zona glomerulosa of the adrenal cortex following chronic immobilization stress. VDUP1 expression was up-regulated in the zona glomerulosa and the adrenal medulla following chronic immobilization stress. These results show that Pref-1 and VDUP1 may be novel genes responding to chronic immobilization stress in adrenal gland.

Keyword

Preadipocyte factor-1 (Pref-1); Vitamin D3 up-regulated protein 1 (VDUP1); Chronic immobilization stress; Adrenal gland

MeSH Terms

Adrenal Cortex
Adrenal Glands*
Adrenal Medulla
Animals
Cholecalciferol*
Immobilization*
In Situ Hybridization
Oxidative Stress
Pancreas
Pituitary Gland
Rats*
Testis
Vitamins*
Zona Glomerulosa
Cholecalciferol
Vitamins