Korean J Anat.  1999 Oct;32(5):697-707.

Epidermal Growth Factor Receptor and Nerve Growth Factor Receptor in the Rat Mandibular Molar and Incisor after Submandibular Sialadenectomy

• Choi HG
• Kim JG
• Cho ES

Abstract

Immunohistochemical changes of epidermal growth factor receptor (EGFR) and nerve growth factor receptor (NGFR) were investigated in the rat mandibular molar and incisors after submandibular sialadenectomy. In the sham operated rat, any EGFR immunoreactivity was not observed in the teeth but NGFR immunoreactivities were observed exclusively in the periodontal ligament and ameloblasts of incisor. In the sialadenectomized rat, EGFR immunoreac-tivities were observed in the odontoblasts of the mandibular first molar, periodontal ligament cells, ameloblasts of incisor and some cells of bone marrow. NGFR immunoreactivities were more intense and widely distributed in alveolar bone, periodontal ligaments and odontoblasts of the sialadenectomized rat than in the sham operated rat. Both of EGFR and NGFR immunoreactivities gradually increased in their intensities in a time-dependent manner after submandibular sialadenectomy. The results show that expression of EGFR and NGFR in the mandibular molar and incisor is enhanced by submandibular sialadenectomy. Therefore, it is suggested that EGF and NGF derived from submandibular gland may affect to the mandibular molar and incisors by direct and/or indirect mechanism.

Keyword

Nerve growth factor receptor; Epidermal growth factor receptor; Sialadenectomy; Mandibular teeth; Immunohistochemistry

MeSH Terms

Ameloblasts
Animals
Bone Marrow
Epidermal Growth Factor*
Immunohistochemistry
Incisor*
Molar*
Nerve Growth Factor
Odontoblasts
Periodontal Ligament
Rats*
Receptor, Epidermal Growth Factor*
Submandibular Gland
Tooth
Epidermal Growth Factor
Nerve Growth Factor
Receptor, Epidermal Growth Factor