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Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps

Zhang YN, Song J, Zhai GT, Wang H, Luo RZ, Li JX, Liao B, Ma J, Wang H, Lu X, Liu DB, Liu Z

PURPOSE: Plasma cells and immunoglobulins (Igs) play a pivotal role in the induction and maintenance of chronic inflammation in nasal polyps. During secondary immune responses, plasma cell survival and Ig...
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Treatment with low-energy shock wave alleviates pain in an animal model of uroplakin 3A-induced autoimmune interstitial cystitis/painful bladder syndrome

Li H, Zhang Z, Peng J, Xin Z, Li M, Yang B, Fang D, Tang Y, Guo Y

PURPOSE: To investigate whether treatment with low-energy shock wave (LESW) alleviates pain and bladder dysfunction in a mouse model of uroplakin 3A (UPK3A)-induced interstitial cystitis/painful bladder syndrome (IC/PBS). MATERIALS AND METHODS:...
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Short-term Haze Exposure Predisposes Healthy Volunteers to Nasal Inflammation

Xian M, Wang K, Lou H, Wang Y, Zhang L, Wang C

PURPOSE: This study aimed to investigate the impact of short-term haze exposure on nasal inflammation in healthy volunteers. METHODS: Thirty-three healthy university students were assessed for nasal symptoms, nasal patency, upper...
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Preparation and Characterization of Human Adipose Tissue-Derived Extracellular Matrix, Growth Factors, and Stem Cells: A Concise Review

Chun SY, Lim JO, Lee EH, Han MH, Ha YS, Lee JN, Kim BS, Park MJ, Yeo M, Jung B, Kwon TG

BACKGROUND: Human adipose tissue is routinely discarded as medical waste. However, this tissue may have valuable clinical applications since methods have been devised to effectively isolate adipose-derived extracellular matrix (ECM),...
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Chemical Constituents of Impatiens balsamina Stems and Their Biological Activities

Kim DH, Lee TH, Subedi L, Kim SY, Lee KR

The purification of the MeOH extract from Impatiens balsamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2 – 12)....
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Neurobiological understanding of suicide

Kim S, Lee KU

Suicide is a complex phenomenon resulting from interactions between individual vulnerabilities and socio-environmental factors. The current review primarily focuses on research into the serotonin system, hypothalamic-pituitary-adrenal axis, neurotrophic factors, lipid...
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Mouse Nerve Growth Factor Facilitates the Growth of Interspinal Schwannoma Cells by Activating NGF Receptors

Liu SY, Liu SZ, Li Y, Chen S

OBJECTIVE: Nerve growth factor (NGF) is a member of the neurotrophic factor family and plays a vital role in the physiological processes of organisms, especially in the nervous system. Many...
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Stem cell therapy in pain medicine

Han YH, Kim KH, Abdi S, Kim TK

Stem cells are attracting attention as a key element in future medicine, satisfying the desire to live a healthier life with the possibility that they can regenerate tissue damaged or...
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A Novel Bio-Psychosocial-Behavioral Treatment Model of Panic Disorder

Park SC, Kim YK

To conceptualize a novel bio-psychosocial-behavioral treatment model of panic disorder (PD), it is necessary to completely integrate behavioral, psychophysiological, neurobiological, and genetic data. Molecular genetic research on PD is specifically...
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Potential Mechanisms Underlying the Increased Excitability of the Bladder Afferent Pathways in Interstitial Cystitis/Bladder Pain Syndrome

Kim DS

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic debilitating disorder associated with lower urinary tract symptoms, including frequency, urgency, and suprapubic pain, which inconveniences the patients and seriously impairs their...
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Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway

Zhang Z, Liu Y, Zhu X, Wei L, Zhu J, Shi K, Wang G, Pan L

Previous studies have shown that the sciatic nerve has neurotrophic activity, and nerve regeneration, differentiation, and axon outgrowth can be modulated by different sciatic nerve preparations. However, numerous animals may...
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Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling

Park JC, Chang IB, Ahn JH, Kim JH, Song JH, Moon SM, Park YH

OBJECTIVE: Notch receptors are heterodimeric transmembrane proteins that regulate cell fate, such as differentiation, proliferation, and apoptosis. Dysregulated Notch pathway signaling has been observed in glioblastomas, as well as in...
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Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and Inflammatory Changes in Rats

Lee S, Kim HB, Hwang ES, Kim ES, Kim SS, Jeon TD, Song MC, Lee JS, Chung MC, Maeng S, Park JH

Depression causes mental and physical changes which affect quality of life. It is estimated to become the second most prevalent disease, but despite its commonness, the pathophysiology of depression remains...
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Schwann Cells Enhance Penetration of Regenerated Axons into Three-Dimensional Microchannels

Liu C, Kray J, Chan C

Nerve regeneration after injury requires proper axon alignment to bridge the lesion site and myelination to achieve functional recovery. Transplanted scaffolds with aligned channels, have been shown to induce axon...
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Rapid-Acting Antidepressant Effect of Ketamine and Its Clinical Application

Kim YK, Shin C

Although the biological causes of depression have been well established, the current use of antidepressants are still mostly based on the monoamine hypothesis of depression. However, monoamine antidepressants delay treatment...
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Add-on Therapy With the α-Blockers Tamsulosin and Naftopidil Improves Voiding Function by Enhancing Neuronal Activity in Prostatic Hyperplasia Rats

Ko IG, Hwang L, Jin JJ, Kim SH, Han JH, Jeon JW, Cho ST

PURPOSE: Benign prostatic hyperplasia (BPH) impacts quality of life in men by causing lower urinary tract symptoms. α1-Adrenoceptor (α1-AR) blockers improve lower urinary tract symptoms. We investigated the efficacy of...
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Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo

Kim S, Moon GJ, Oh YS, Park J, Shin WH, Jeong JY, Choi KS, Jin BK, Kholodilov N, Burke RE, Kim HJ, Ha CM, Lee SG, Kim SR

We recently reported that adeno-associated virus serotype 1 (AAV1) transduction of murine nigral dopaminergic (DA) neurons with constitutively active ras homolog enriched in brain with a mutation of serine to...
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The Efficacy and Underlying Mechanism of Moxibustion in Preventing Cognitive Impairment: A Systematic Review of Animal Studies

Choe S, Cai M, Jerng UM, Lee JH

Cognitive impairment is age-related and manageable only with early diagnosis and prevention. Moxibustion is widely accepted in East Asia as useful for preventing cognitive impairment. This systematic review of animal...
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Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target

Tsai MS, Lee PH, Sun CK, Chiu TC, Lin YC, Chang IW, Chen PH, Kao YH

This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in...
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Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and the GDNF Family Receptor Alpha Subunit 1 in the Paravaginal Ganglia of Nulliparous and Primiparous Rabbits

García-Villamar V, Hernández-Aragón LG, Chávez-Ríos JR, Ortega A, Martínez-Gómez M, Castelán

PURPOSE: To evaluate the expression of glial cell line-derived neurotrophic factor (GDNF) and its receptor, GDNF family receptor alpha subunit 1 (GFRα-1) in the pelvic (middle third) vagina and, particularly,...
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