Korean J Med.
1997 Apr;52(4):470-475.
A Study on the Calcium-Binding Protein in Gallbladder Bile
- Affiliations
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- 1Department of Internal Medicine, Gallstone Study Group, Asan Medical Center, University of Ulsan, Seoul, Korea.
Abstract
OBJECTIVES
Calcium salts are usually present in the center of all types of gallstones, including pure cholesterol stones. It has been postulated that precipitation of calcium salts might act as a nidus for gallstone formation. Our goal was to determine whether a calcium-binding protein was present in bile and whether this protein has any calcium-binding properties.
METHODS
Calcium-binding moiety was obtained by addition of CaC12 into the gallbladder bile. Calcium-binding protein was identified by SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis). The capacity to bind calcium was confirmed by autoradiography with 45Ca++.
RESULTS
We identified a protein(M.W.
The presence of calcium-binding protein in bile and its ability to bind calcium suggest that it may play a functional role in the pathogenesis of gallstones.
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