Korean J Nephrol.  2010 Nov;29(6):752-760.

Risk Factors Influencing Decline of Residual Renal Function in Patients on Continuous Ambulatory Peritoneal Dialysis

• Kim GH
• Hyun SH
• Seo HJ
• Choi JY
• Cho JH
• Kim CD
• Park SH
• Kim YL

Abstract

PURPOSE
Preservation of residual renal function (RRF) after initiation of peritoneal dialysis (PD) is beneficial for patient survival. It is unclear that same risk factors of pre-dialysis chronic kidney disease (CKD) patients affect RRF in PD patients. This study was aimed to evaluate factors affecting RRF after commencement of PD.
METHODS
Data from 80 patients commencing CAPD at Kyungpook National University Hospital between January 2001 and December 2008 were retrospectively collected. After PD commencement, biochemical and clinical data at baseline (1 month), 6, and 12 month were obtained. RRF was calculated as the average of creatinine clearance and urea nitrogen clearance from 24-hour urine collection and normalized with body surface area and mean RRF decline rate was calculated by dividing RRF difference between baseline to 12 month by period.
RESULTS
Mean RRF decline rate (mL/min/1.73m2/month) was negatively correlated with left ventricular posterior wall thickness (LVPWT) (R2=0.097, p=0.023) and proteinuria (R2=0.126, p=0.003), whereas positively correlated with hematocrit (R2=0.076, p=0.013) at baseline.
CONCLUSION
Decline of RRF during a year after commencement of PD was associated with baseline proteinuria and LVPWT.

Keyword

Continuous ambulatory peritoneal dialysis; Proteinuria; Left ventricular hypertrophy

MeSH Terms

Body Surface Area
Creatinine
Hematocrit
Humans
Hypertrophy, Left Ventricular
Nitrogen
Peritoneal Dialysis
Peritoneal Dialysis, Continuous Ambulatory
Proteinuria
Renal Insufficiency, Chronic
Retrospective Studies
Risk Factors
Urea
Urine Specimen Collection
Creatinine
Nitrogen
Urea