Korean J Nephrol.  2006 Jan;25(1):99-102.

Chinese Herbs Induced End-Stage Renal Disease in a Patient with Minimal Change Nephrotic Syndrome

Affiliations
  • 1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. drsong@catholic.ac.kr

Abstract

An outbreak of rapidly progressive renal failure was observed in Belgium in 1993 and was related to a slimming regimen involving Chinese herbs. Extensive interstitial fibrosis with atrophy and tubular loss was the major histological lesion. Aristolochic acid has been suspected to be responsible for nephrotoxicity. The use of Chinese herbal medicines is very popular in Korea. We report the presence of a nephrotoxic compound in herb medications, which led to end-stage renal failure in a patient with complete remission state of minimal change disease. The typical and sequential pathologic changes in our patient following the consumption of herbs suggest possible relationship to herbal medicines, and end-stage renal disease, despite the fact that a cause-and-effect relationship cannot be automatically inferred.

Keyword

Chinese herb; Nephrosis; Lipoid; Renal failure; Chronic

MeSH Terms

Asian Continental Ancestry Group*
Atrophy
Belgium
Fibrosis
Humans
Kidney Failure, Chronic*
Korea
Nephrosis
Nephrosis, Lipoid*
Renal Insufficiency
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