Korean J Nephrol.  2007 Nov;26(6):736-739.

Minimal Change Nephrotic Syndrome After Apitoxin Therapy: A Case Report

• Kim JO
• Shin BC
• Kim HL
• Chung JH

Abstract

Bee stings have previously been implicated in the development of nephrotic syndrome, but the reported cases in the literature are rare. Furthermore, there has been no case of nephrotic syndrome after bee venom (apitoxin) therapy. We experienced a 28-year-old female who developed generalized edema 6 days after an intramuscular injection of apitoxin. The physical examination and laboratory findings were relevant with nephrotic syndrome and the renal biopsy revealed minimal change nephrotic syndrome. The corticosteroid treatment induced prompt remission with resolution of edema and normalization of the laboratory findings. There was no relapse of the disease during the 6-month follow-up. We report this case together with brief review of literatures.

Keyword

Minimal change nephrotic syndrome; Apitoxin; Corticosteroids

MeSH Terms

Adrenal Cortex Hormones
Adult
Bee Venoms*
Bees
Biopsy
Bites and Stings
Edema
Female
Follow-Up Studies
Humans
Injections, Intramuscular
Nephrosis, Lipoid*
Nephrotic Syndrome
Physical Examination
Recurrence
Adrenal Cortex Hormones
Bee Venoms