Korean J Obstet Gynecol.  2001 Mar;44(3):594-600.

Clinical Characteristics of Two Types of Endometrial Cancer

• Park YH
• Ryu HS
• Joo HJ
• Lee JP
• Oh KS

Abstract

OBJECTIVE
The endometrial cancer can be divided into two large groups on the base of carcinogenesis according to the pathologic findings. The hormone induced cancer group(type 1) represents the cancers developed under the effects of unopposed estrogen. And the other group(type 2) can be developed by the mechanisms of divergent variable events such as mutations or gene deletions. These two different types show definite differences in clinical characteristics.
METHODS
Clinical features of the 43 patients who were diagnosed and were treated as endometrial cancer in Gynecologic department of Ajou University Hospital from June 1994 to November 2000 were evaluated according to the pathologic findings. 22 patients of type 1 and 17 patients of type 2 were classified and analysed statistically.
RESULTS
Age, cell types, grade, cancer stage, endometrial thickness, invasion depth of uterine walls were definitely different with statistic significance. The lymphovascular space invasion, the number of lymph node metastasis, pap smear of cervix, adnexal involvement, diabetes, hypertension, CA125, gravida, height were not different between two groups statistically in correlations. BMI shown marked difference but had no statistical significance.
CONCLUSIONS
The classification of endometrial cancer into the two types is very significant because it can allow avoidance of preceding risk factors and can provide the alteration of treatment tendency and the expectation of benign or malignant prognosis, clinically.

Keyword

Endometrial cancer; Pathologic type; Prognosis

MeSH Terms

Carcinogenesis
Cervix Uteri
Classification
Endometrial Neoplasms*
Estrogens
Female
Gene Deletion
Humans
Hypertension
Lymph Nodes
Neoplasm Metastasis
Prognosis
Risk Factors
Estrogens