J Vet Sci.
2014 Dec;15(4):575-578. 10.4142/jvs.2014.15.4.575.
Induction of antibody and interferon-gamma production in mice immunized with virus-like particles of swine hepatitis E virus
- Affiliations
-
- 1Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea. ischoi@konkuk.ac.kr
- 2Department of Public Health, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
- 3Department of Biomedical Science and Technology, SMART Institute of Advanced Biomedical Science, Konkuk University, Seoul 143-701, Korea.
- 4Animal and Plant Quarantine Agency, Anyang 430-855, Korea.
- 5Veterinary Science Research Institute, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
- KMID: 2070246
- DOI: http://doi.org/10.4142/jvs.2014.15.4.575
Abstract
- Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-gamma than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-gamma production in immunized mice.
MeSH Terms
-
Animals
Antibodies, Viral/blood
Capsid Proteins/immunology
Female
Hepatitis E/immunology/*veterinary/virology
Hepatitis E virus/*immunology
Immunization/*veterinary
Interferon-gamma/blood
Mice
Mice, Inbred BALB C
Swine
Swine Diseases/*immunology/virology
Vaccines, Virus-Like Particle/immunology
Viral Hepatitis Vaccines/*immunology
Antibodies, Viral
Capsid Proteins
Interferon-gamma
Vaccines, Virus-Like Particle
Viral Hepatitis Vaccines
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Prevention of Viral Hepatitis and Vaccination
- Characterization of Monoclonal Antibody Specific for Hepatitis C Virus E2 Envelope Protein
- Generation, characterization, and application in serodiagnosis of recombinant swine vesicular disease virus-like particles
- Randomized, controlled trial of recombinant human gamma-interferon in chronic hepatitis B infection
- Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+ T Cell Activity
