J Vet Sci.  2014 Dec;15(4):575-578. 10.4142/jvs.2014.15.4.575.

Induction of antibody and interferon-gamma production in mice immunized with virus-like particles of swine hepatitis E virus

Affiliations
  • 1Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea. ischoi@konkuk.ac.kr
  • 2Department of Public Health, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
  • 3Department of Biomedical Science and Technology, SMART Institute of Advanced Biomedical Science, Konkuk University, Seoul 143-701, Korea.
  • 4Animal and Plant Quarantine Agency, Anyang 430-855, Korea.
  • 5Veterinary Science Research Institute, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.

Abstract

Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-gamma than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-gamma production in immunized mice.

Keyword

interferon-gamma; swine hepatitis E virus; virus-like particle
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