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Performance Evaluation of a New Automated Chemiluminescent Immunoanalyzer-Based Interferon-Gamma Releasing Assay AdvanSure I3 in Comparison With the QuantiFERON-TB Gold In-Tube Assay

Kim JJ, Park Y, Choi D, Kim HS

BACKGROUND: The interferon-gamma (IFN-γ) releasing assay (IGRA) is widely used for latent tuberculosis infection (LTBI) diagnosis. We evaluated the analytical performance of a new automated chemiluminescent immunoanalyzer-based IGRA (CLIA-IGRA), AdvanSure...
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Distinct Inflammation Biomarkers in Healthy Individuals and Patients with Schizophrenia: A Reliability Testing of Multiplex Cytokine Immunoassay by Bland-Altman Analysis

Yeh TC, Chu HT, Tsai CK, Chang HA, Yang FC, Huang SY, Liang CS

OBJECTIVE: Since the inflammatory process has been implicated in the pathophysiology of psychiatric disorder, an important issue emerging is to assess the test-retest reliability of cytokine measurement in healthy individuals...
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Proposal to Revise the Screening Test for Latent Tuberculosis Infection in Close Contacts at Elementary Schools in Korea

Bae JM

The 2018 National Guideline for Tuberculosis Control, which was published by the Korea Centers for Diseases Prevention and Control (KCDC), mandates conducting an epidemiological survey among close contacts of active...
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Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases

Ünüvar S, Erge D, Kılıçarslan B, Gözükara Bağ HG, Çatal F, Girgin G, Baydar T

BACKGROUND: Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-γ) stimulation. We investigated...
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The Performance of the Agility System for Interferon Gamma Release Assay Using QuantiFERON TB Gold In-Tube Assay

Seok K, Shin S

BACKGROUND: As stated in ‘The Action Strategy for Tuberculosis-Free Korea,’ last March, high-throughput, large-scale analytical instruments for interferon gamma release assays (IGRA) are demanded by many clinical laboratories using the...
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Screening and Treatment of Latent Tuberculosis Infection among Healthcare Workers at a Referral Hospital in Korea

Park SY, Lee E, Lee EJ, Kim TH, Kim YK

BACKGROUND: Healthcare workers (HCWs) have a high risk of tuberculosis (TB) infection. Since August 2017, Korea has mandated the testing of latent TB infection (LTBI) and recommended treatment from HCWs...
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Analysis of Prevalence and Risk Factors for Latent Tuberculosis Infection among Healthcare Workers

Lee JB, Choi JS

PURPOSE: The purpose of this study was to provide basic data on the infection prevention management program, which is one of the infectious disease control program by identifying the prevalence...
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Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1

Zhang P, Yu J, Gui Y, Sun C, Han W

PURPOSE: Staphylococcal enterotoxin B (SEB) has been well-documented to induce liver injury. miRNA-222-3p (miR-222-3p) was implicated in SEB-induced lung injury and several liver injuries. This study aimed to explore the...
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Good Agreement between an Interferon Gamma Release Assay and Tuberculin Skin Tests in Testing for Latent Tuberculosis Infection among HIV-Infected Patients in Indonesia

Reviono R, Saptawati , Redhono D, Suryawati

BACKGROUND: Latent tuberculosis infection is a condition where there is a persistent immune response to Mycobacterium tuberculosis without clinical manifestations of tuberculosis. Currently, there is no gold standard to diagnose...
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Experiences of Latent Tuberculosis Infection Treatment for the North Korean Refugees

Kim BK, Kim HJ, Kim HJ, Cha JH, Lee JB, Jeon J, Kim CY, Kim Y, Kim JH, Shin C, Lee SH

BACKGROUND: Tuberculosis (TB) is increasing in immigrants. We aimed to investigate the current status of latent tuberculosis infection (LTBI) treatment for North Korean Refugees (NKR) compared to South Koreans Contacts...
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Diagnosis and treatment of latent tuberculosis infection

Min J, Kim JS

In order to eliminate tuberculosis worldwide by 2050, effective management of latent tuberculosis infection is essential, and policy-makers have begun to recognize the importance of scaling up preventive therapy. The...
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Thapsigargin Increases IL-2 Production in T Cells at Nanomolar Concentrations

Kim KH, Kim SH, Jung HH, Moon JH, Jeong SU, Yu K, Lee CK

Thapsigargin (TGN) is a potent and selective inhibitor of sarco-endoplasmic Ca²⁺-ATPase, leading to rapid elevation of cytoplasmic Ca2+ concentration. Previous reports have shown that TGN increases the production of various...
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Decreased IL-1ra and NCAM-1/CD56 Serum Levels in Unmedicated Patients with Schizophrenia Before and After Antipsychotic Treatment

Chu CS, Li DJ, Chu CL, Wu CC, Lu T

OBJECTIVE: Schizophrenia (SZ) has been associated with the inflammatory-related and immunological pathogenesis. This study investigates the aberration of cytokines in patients with SZ. METHODS: Thirty patients with SZ without antipsychotic treatment...
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Diagnosis, Treatment and Clinical Features of Cutaneous Leishmaniasis in Saudi Arabia

Hawash YA, Ismail KA, Abdel-Wahab MM, Khalifa M

Cutaneous leishmaniasis (CL) has been one of the most common parasitic diseases in Saudi Arabia. This study exhibits the clinical features, diagnosis, cytokine profile and treatment of CL patients in...
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Association between endotoxin levels in dust from indoor swine housing environments and the immune responses of pigs

Roque K, Shin KM, Jo JH, Lim GD, Song ES, Shin SJ, Gautam R, Lee JH, Kim YG, Cho AR, Kim CY, Kim HJ, Lee MS, Oh HG, Lee BC, Kim JH, Kim KH, Jeong HK, Kim HA, Heo Y

Indoor animal husbandry environments are inevitably contaminated with endotoxins. Endotoxin exposure is associated with various inflammatory illnesses in animals. This cross-sectional study evaluated the relationship between the degree of endotoxin...
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Variable Natural Killer Cell Activity in Hematological Malignancies at Diagnosis

Park S, Mun YC, Seong CM, Huh HJ, Huh J

BACKGROUND: Natural killer (NK) cells play a key role in innate immune responses and are an important component of anti-cancer defenses. This study aimed to investigate the clinicopathological characteristics of...
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A Case of Drastically Aggravated Erythema Induratum due to Co-existing Peripheral Arterial Occlusive Disease

Kang JN, Seol JE, Kim DH, Park SH, Kim H

  • KMID: 2436671
  • Korean J Dermatol.
  • 2018 Mar;56(3):206-209.
A 72-year-old woman presented with recurrent painful erythematous nodules and ulcers on both legs. Latent tuberculosis was proven by a positive interferon-gamma release assay, and a histopathology examination revealed septolobular...
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Diagnosis and Treatment of Latent Tuberculosis Infection: The Updated 2017 Korean Guidelines

Lee SH

A small number of viable tuberculosis bacilli can reside in an individual with latent tuberculosis infection (LTBI) without obvious clinical symptoms or abnormal chest radiographs. Diagnosis and treatment of LTBI...
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Systemic review: agreement between the latent tuberculosis screening tests among patients with rheumatic diseases

Pyo J, Cho SK, Kim D, Sung YK

BACKGROUND/AIMS: To estimate the level of agreement and positivity rates of latent tuberculosis infection (LTBI) tests prior to the use of tumor necrosis factor (TNF) inhibitors in relation to underlying...
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Incidence of Active Tuberculosis within One Year after Tumor Necrosis Factor Inhibitor Treatment according to Latent Tuberculosis Infection Status in Patients with Inflammatory Bowel Disease

Kang J, Jeong DH, Han M, Yang SK, Byeon JS, Ye BD, Park SH, Hwang SW, Shim TS, Jo KW

BACKGROUND: We investigated the incidence of active tuberculosis among patients with inflammatory bowel disease (IBD) treated with tumor necrosis factor (TNF) inhibitors, with or without latent tuberculosis infection (LTBI). METHODS: The...
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