J Korean Assoc Maxillofac Plast Reconstr Surg.  2007 May;29(3):262-267.

The review of transmission of infectious disease in human tissue transplantation: Phase II. allogenic soft tissues

• Lee EY
• Kim KW
• Um IW

Abstract

Implantation of allografts has increased widely with not only the availability of many allogenic bone but also allogenic soft tissues. The aim of tissue banking is to provide surgeons with safe tissues compatible with their intended clinical application. The incidence of tissue transplant-transmitted infection is unknown and can only be inferred from prospective studies. The possibility of donor-to-recipient disease transmission through soft tissue transplantation can be considered by reviewing the risk associated with other transplanted hard tissues. Viral, bacterial, and fungal infections have been transmitted via transplantation of soft tissue allografts such as skin, cornea, dura, pericardium. fascia lata, and heart valves. Corneas have transmitted rabies, Creutzfeldt-Jakob disease (CJD), hepatitis B (HBV), cytomegalovirus (CMV), herpes simplex virus (HSV), bacteria, and fungi. Heart valves have been implicated in transmitting tuberculosis, hepatitis B. HIV-1 and CMV. CJD has been transmitted by dura and pericardium transplants. Skin has transmitted CMV, bacteria, and fungi. Cadaveric skin, pericardium, dura, and fascia lata have been used in dental patients with intra-oral soft tissue injuries and GBR. This study is review of the considering transmission of infectious disease in allogenic soft tissues and guidelines of reducing the risk. Prior to use, many tissues are exposed to antibiotics, disinfectants, and sterilants, which further reduce or remove the risk of transmitted disease. Because some soft tissue grafts cannot be subjected to sterilization steps, the risk of infectious disease transmission remains and thorough donor screening and testing is especially important.

Keyword

Skin; Fascia lata; Pericardium; Infectious diseases; Processing

MeSH Terms

Allografts
Anti-Bacterial Agents
Bacteria
Cadaver
Communicable Diseases
Cornea
Creutzfeldt-Jakob Syndrome
Cytomegalovirus
Disease Transmission, Infectious*
Disinfectants
Donor Selection
Fascia Lata
Fungi
Heart Valves
Hepatitis B
HIV-1
Humans*
Incidence
Pericardium
Rabies
Simplexvirus
Skin
Soft Tissue Injuries
Sterilization
Tissue Banks
Tissue Transplantation*
Transplants*
Tuberculosis
Anti-Bacterial Agents
Disinfectants