J Korean Med Sci.  2014 Nov;29(Suppl 3):S170-S175. 10.3346/jkms.2014.29.S3.S170.

Injectable Tissue-Engineered Soft Tissue for Tissue Augmentation

• Rhee SM
• You HJ
• Han SK

• KMID: 2151410
• DOI: http://doi.org/10.3346/jkms.2014.29.S3.S170

Abstract

Soft tissue augmentation is a process of implanting tissues or materials to treat wrinkles or soft tissue defects in the body. Over the years, various materials have evolved to correct soft tissue defects, including a number of tissues and polymers. Autogenous dermis, autogenous fat, autogenous dermis-fat, allogenic dermis, synthetic implants, and fillers have been widely accepted for soft tissue augmentations. Tissue engineering technology has also been introduced and opened a new venue of opportunities in this field. In particular, a long-lasting filler consisting of hyaluronic acid filler and living human mesenchymal cells called "injectable tissue-engineered soft tissue" has been created and applied clinically, as this strategy has many advantages over conventional methods. Fibroblasts and adipose-derived stromal vascular fraction cells can be clinically used as injectable tissue-engineered soft tissue at present. In this review, information on the soft tissue augmentation method using the injectable tissue-engineered soft tissue is provided.

Keyword

Cell Therapy; Soft Tissue; Tissue Engineering

MeSH Terms

Adipocytes/transplantation
Adipose Tissue/cytology
Biocompatible Materials
Connective Tissue/*surgery
Dermatologic Surgical Procedures/*methods
Face
Fibroblasts/transplantation
Humans
Hyaluronic Acid/therapeutic use
Injections, Intradermal
Mesenchymal Stem Cell Transplantation/*methods
Mesenchymal Stromal Cells
Skin
Skin Aging
Tissue Engineering/*methods
Biocompatible Materials
Hyaluronic Acid