Clin Pediatr Hematol Oncol.  2012 Oct;19(2):118-122.

A Case of Oligodendroglioma after Treatment of Acute Lymphoblastic Leukemia in Childhood

• Shin SH
• Chung BH
• Bauer S
• Lee JH
• Lee KC

Abstract

Secondary brain tumors after cranial irradiation have been reported in survivors of childhood acute lymphoblastic leukemia (ALL). We report a case of secondary oligodendroglioma, occurring in a 19-year-old male, 12 years after the diagnosis of ALL. He was treated with vincristine, asparaginase, doxorubicin, methotrexate, prednisone, 6-mercaptopurine and cytarabine followed by prophylactic cranial irradiation at the age of 7 years. After treatment of ALL was completed at the age of 10 years, he showed symptoms of seizure, headache and decreased visual acuity at the age of 19 years. Magnetic resonance imaging (MRI) of the brain showed a mass lesion which was revealed as low-grade oligodendroglioma by stereotactic biopsy. He was treated with cranial radiotherapy, followed by 4 cycles of chemotherapy composed of PCV (procarbazine, methyl-1-(2-chloroethyl)-1-nitrosourea (CCNU), and vincristine) for oligodendroglioma, and sodium valproate for seizure control. The patient showed stable disease and no recurrence of seizure 8 months after treatment.

Keyword

Oligodendroglioma; Childhood; Acute lymphoblastic leukemia; Cranial irradiation

MeSH Terms

6-Mercaptopurine
Asparaginase
Biopsy
Brain
Brain Neoplasms
Cranial Irradiation
Cytarabine
Doxorubicin
Headache
Humans
Magnetic Resonance Imaging
Male
Methotrexate
Oligodendroglioma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prednisone
Recurrence
Seizures
Survivors
Valproic Acid
Vincristine
Visual Acuity
Young Adult
6-Mercaptopurine
Asparaginase
Cytarabine
Doxorubicin
Methotrexate
Prednisone
Valproic Acid
Vincristine