J Korean Orthop Res Soc.
2007 Apr;10(1):10-15.
Immunohistochemical Demonstration of Nerve Fibers of the Human Knee Synovium
- Affiliations
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- 1Department of Orthopaedics Surgery, College of Medicine, Wonkwang University Hospital. yjkim1@wonkwang.ac.kr
- 2Department of Pathology, College of Medicine, Wonkwang University Hospital.
Abstract
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PURPOSE: To demonstrate the presence of nerve fibers including nociceptive fibers in synovium of human knee joint using immunohistochemistry.
MATERIALS AND METHODS
10 Synovial membrane tissues of knee joint obtained from 5 cadavers were analyzed immunohistochemically using antibodies to protein gene product 9.5, betaIII-tubulin, substance P and calcitonin gene-related peptide (CGRP).
RESULTS
Many nerve fibers immunoreactive for protein gene product 9.5 and betaIII-tubulin were demonstrated in synovial folds of human knee joints. Also, immunostaining showed the presence of free nerve ending fibers immunoreactive for substance P and calcitonin gene-related peptide in synovium.
CONCLUSION
The presence of putative nerve fibers including nociceptive fibers in synovial folds supports a possible role for theses structures as source of knee joint pain.
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