J Korean Ophthalmol Soc.
1996 Apr;37(4):602-607.
Effects of Antimetabolites on Proliferation of Rabbit Retinal Pigment Epithelial Cells
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- 1Department of Opthalmology, College of Medicine, Kyung Hee University, Seoul, Korea.
Abstract
- Inspite of technical advances, the need for pharmacologic treatment of proliferative vitreoretinopathy was increased. In order to evaluate the antiproliferative effect of various antimetabolites to the rabbit retinal pigment epithelial cell, we treated cultured rabbit retinal pigment epithelial cell with different concentration of drugs to perform dose inhibition studies. We found that the antimetabolites inhibited the proliferation of rabbit retinal pigment epithelial cell in a dose dependent and a time dependent manner. The drug concentration required for 50% inhibition of cell growth (ID50) were found to be as follows (BCNU; 6.51 mg/L, 5-FU ; 8.94 mg/L, Daunorubicin; 0.03mg/L, Mitomycin-C; 0.26mg/L).
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