J Korean Ophthalmol Soc.  1987 Dec;28(6):1239-1245.

The Effect of 5-Fluorouraci1 on the Activity of the Retinal Pigment Epithelium in Vitro

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  • 1Department of Ophthalmology, Hanyang University, School of Medicine, Seoul, Korea.

Abstract

Fluorouracil Was effective in controlling the in vitro cellular proliferation. When given with cultured human retinal pigment epithelial cell, fluoroirracil decreased the cellular activity of the cultured retinal pigment epithelial cell. The attachment and migratien of the cultured retinal pigment epithelial cell was markedly reduced after repeated treatment with fluorouracil. Electron micrographs of the cultured retinal pigment epithelial cell given with fluorouracil showed marked reduction of cytoplasmic pseudopodia, rupture of plasma membrane, loss of microorganelles and eventual cytolysis. Based on these data, low dose fluorouracil may be an effective inhibitor of the in vitro proliferation of the retinal pigment epithelium.

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