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Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells

Shim HJ, Park SY, Kwon HS, Song WJ, Kim TB, Moon KA, Choi JP, Kim SJ, Cho YS

PURPOSE: Reduction-oxidation reaction homeostasis is vital for regulating inflammatory conditions and its dysregulation may affect the pathogenesis of chronic airway inflammatory diseases such as asthma. Peroxiredoxin-6, an important intracellular anti-oxidant...
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A Case of Cutaneous Spindle Cell Squamous Cell Carcinoma Arising in a Nevus Sebaceous

Oh YW, Kim DH, Seo BH, Suh HS, Choi YS

No abstract available.
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Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells

Cheon YH, Kim MS, Kim JY, Kim DH, Han SY, Lee JH

Chronic inflammatory airway diseases, such as chronic rhinosinusitis, chronic obstructive pulmonary disease, and asthma, are associated with excessive mucus production. Hence, the regulation of mucus production is important for the...
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Magnetic Resonance Imaging Findings Differentiating Cutaneous Basal Cell Carcinoma from Squamous Cell Carcinoma in the Head and Neck Region

Kawaguchi , Kato H, Tomita H, Hara A, Suzui N, Miyazaki T, Matsuyama , Seishima M, Matsuo M

OBJECTIVE: This study aimed to evaluate the efficacy of magnetic resonance (MR) imaging in differentiating between cutaneous basal cell carcinoma (cBCC) and cutaneous squamous cell carcinoma (cSCC) in the head...
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Primary Nasal Epithelial Cells From Allergic and Non-allergic Individuals Show Comparable Barrier Function

Waltl EE, Stanek V, Mueller CA, Kiss R, Eckl-Dorna J, Valenta R, Niederberger V

Previous reports suggested that ex vivo cultured primary nasal epithelial cells from allergic patients differ from those from non-allergic individuals by genuinely reduced barrier function. By contrast, we found that...
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Effect of Diquafosol on Hyperosmotic Stress-induced Tumor Necrosis Factor-α and Interleukin-6 Expression in Human Corneal Epithelial Cells

Kim YH, Yang IJ, Nguyen LT, Gum SI, Yu S, Lee GJ, Kim BA, Jung JC, Park YJ

PURPOSE: Diquafosol is a pharmaceutical drug used for dry eye treatment with a novel mechanism of action. It is a purinergic P2Y2 receptor agonist that promotes the secretion of tears...
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Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells

Xian M, Ma S, Wang K, Lou H, Wang Y, Zhang L, Wang C, Akdis CA

PURPOSE: The effect of air pollution-related particulate matter (PM) on epithelial barrier function and tight junction (TJ) expression in human nasal mucosa has not been studied to date. This study...
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Effects of dental acid etchants in oral epithelial cells

Kim DK, Kwak JW, Jo RM, Jung DS, Youn DY, Oh NY, Jang JH

Phosphoric acid (P.A.; 37%) can induce necrosis on the oral mucosa and cause the ulceration of periodontal tissue. However, most studies reported are clinical case studies, with few basic science...
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Prognostic Value of Combined Programmed Cell Death 1 Ligand and p16 Expression Predicting Responsiveness to Radiotherapy in Patients with Oropharyngeal Squamous Cell Carcinoma

Kwon M, Kim DH, Cho KJ, Kim Y, Kim JP, Jeong BK, Lee JS, Seo JH, Park JJ

BACKGROUND AND OBJECTIVES: This study examined the expressions of p16 and the programmed cell death 1 ligand (PD-L1) in patients with oropharyngeal cancer (OPC) treated with radiotherapy (RT) to identify...
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An Esophageal Squamous Cell Carcinoma with Lymph Node Metastasis Presenting as a Small Subepithelial Tumor

Park JW, Gong EJ, Seo M, Jun BG, Seo HI, Park JK, Han KH, Lee SJ, Kim YD, Jeong WJ, Cheon GJ

A subepithelial tumor-like esophageal carcinoma is rare. We report a case of an esophageal squamous cell carcinoma with lymph node metastasis presenting as a small subepithelial tumor. A 68-year-old man...
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Anti-Helicobacter pylori, Anti-apoptotic, and Cytoprotective Effects of Threonine Synthesized from Corynebacterium glutamicum in Gastric Epithelial Cells

An JM, Kim YS, Hong YG, Hah BS, Sohn MS, Hahm KB

BACKGROUND/AIMS: Among irritants causing gastric ulcer, Helicobacter pylori (H. pylori) might be pivotal, after which eradication became essential way in either inhibiting ulcerogenesis or preventing ulcer recurrence. Since threonine is...
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Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells

Moon D, Yoon SP, Jang HS, Noh MR, Ha L, Padanilam , Kim J

Calcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in primary afferent sensory neurons. Exogenous CGRP can induce cell death in kidney tubular cells. The objective of this study was...
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Cutaneous squamous cell carcinoma: High risk factors, staging and management

Park HJ

Cutaneous squamous cell carconoma(cSCC) is a malignant neoplasm derived from suprabasal epidermal keratinocytes, which is one of the nonmelanoma skin cancers that represent the most common malignancies in humans. Although...
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Comparison of Squamous Cell Carcinoma of the Tongue between Young and Old Patients

Choi G, Song JS, Choi SH, Nam SY, Kim SY, Roh JL, Lee BK, Cho KJ

BACKGROUND: The worldwide incidence of squamous cell carcinoma of the tongue (SCCOT) in young patients has been increasing. We investigated clinicopathologic features of this unique population and compared them with...
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Role of immunoreactive patterns of lymph nodes in neck dissection cases of oral squamous cell carcinoma: a clinical and histopathological study

Bhatlawande HC, Kale AD, Desai KM, Hallikerimath S, Belaldavar C, Mane D, Angadi PV, M M, Muttagi S

OBJECTIVES: Metastasis in oral squamous cell carcinoma (OSCC) can occur in a variety of ways, and draining lymphatics and lymph nodes serve as a common route. Prior to metastasis, lymph...
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Anti-inflammatory effect of remifentanil in lipopolysaccharide–stimulated amniotic epithelial cells

Kim CH, Jeong SS, Park SJ, Choi EJ, Kim YH, Ahn JH

BACKGROUND: Sometimes general anesthesia is required for dental surgery in pregnant women. Facial bone fractures or neck abscess should be treated immediately. Dental surgery, however, creates a stressful situation that...
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β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells

Kim D, Lim JW, Kim H

BACKGROUND: Helicobacter pylori infection is a major risk factor in the development of gastric cancer. H. pylori infection of gastric epithelial cells increases the levels of reactive oxygen species (ROS),...
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New Diagnostic Approach for Esophageal Squamous Cell Neoplasms Using Linked Color Imaging and Blue Laser Imaging Combined with Iodine Staining

Tsunoda M, Miura Y, Osawa H, Khurelbaatar T, Sakaguchi , Fukuda H, Lefor AK, Yamamoto H

A 62-year-old man with a flat early esophageal cancer was referred for endoscopic treatment. White light imaging revealed a pale red lesion, whereas linked color imaging (LCI) and blue laser...
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A Case of Squamous Cell Carcinoma in Situ of the Middle Ear

Park BW, Baek MJ

Malignancy of the middle ear is rare and its estimated incidence is 0.18 cases per million people in the US, with its most common type being squamous cell carcinoma. Squamous...
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Inhibitory Effects of Protopanaxadiol on Lipopolysaccharide-Induced Reactive Oxygen Species Production and MUC5AC Expression in Human Airway Epithelial Cells

Song YS, Kim JH, Na H, Choi YS, Song SY, Kim YD, Bae CH

BACKGROUND AND OBJECTIVES: MUC5AC is one of the major secretory mucin genes in the human airway epithelium. MUC5AC expression is increased by a variety of inflammatory mediators. Protopanaxadiol (PPD), one...
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