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Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells

Hong R, Han SI

The tumor microenvironment greatly influences cancer cell characteristics, and acidic extracellular pH has been implicated as an essential factor in tumor malignancy and the induction of drug resistance. Here, we...
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Uveoretinal Adverse Effects Presented during Systemic Anticancer Chemotherapy: a 10-Year Single Center Experience

Cho AR, Yoon YH, Kim JG, Kim YJ, Lee JY

BACKGROUND: The present study describes our 10-year experience with uveoretinal adverse events that manifest because of chemotherapy. METHODS: A retrospective chart review was performed for all patients who presented to the...
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Clinical features and treatment outcomes of blastic plasmacytoid dendritic cell neoplasm: a single-center experience in Korea

Kim HS, Kim HJ, Kim SH, Choi JY, Ko YH, Kim WS, Jung CW, Kim SJ

BACKGROUND/AIMS: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that typically presents in the form of skin manifestations with or without lymph node and bone marrow involvement....
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Effects of Adamantyl Derivatives on Pharmacokinetic Behavior of Paclitaxel in Rats

Kim KM, Lee K, Jang K, Moon YS, Lee HJ, Rhie SJ

Paclitaxel (PTX) is one of the most frequently used anticancer agent for treating refractory ovarian cancer, metastatic breast cancer and non-small cell lung cancer. However, its oral administration is impeded...
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Analysis of Dermatologic Diseases in Patients Receiving Anticancer Treatments: A Retrospective Study of 140 Cases

Kang JN, Kim DH, Seol JE, Jung SY, Wang HY, Kim H

  • KMID: 2371079
  • Korean J Dermatol.
  • 2017 Feb;55(2):89-95.
BACKGROUND: A number of anticancer agents are known to induce many adverse reactions in the skin. Related cutaneous adverse drug reactions influence the morbidity, mortality, and anti-cancer regimen of the...
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Correlation of NPM1 Type A Mutation Burden With Clinical Status and Outcomes in Acute Myeloid Leukemia Patients With Mutated NPM1 Type A

Jo SY, Park SH, Kim IS, Yi J, Kim HH, Chang CL, Lee EY, Cho YU, Jang S, Park CJ, Chi HS

BACKGROUND: Nucleophosmin gene (NPM1) mutation may be a good molecular marker for assessing the clinical status and predicting the outcomes in AML patients. We evaluated the applicability of NPM1 type...
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Isolated Myeloid Sarcoma Presenting as Cord Compression by Paraspinal Mass

Oh HH, Kim HJ, Han TH, Kwon MK, Bae SY, Yuh YJ

Myeloid sarcoma is a rare tumor mass consisting of immature granulocytic cells occurring in an extramedullary site or in a bone. It has often been observed during the course of...
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A Case of del(16)(q22) in a Patient with Acute Myeloid Leukemia with Complex Karyotype

Kim M, Lee JW, Lee JK, Hong YJ, Hong SI, Kang HJ, Cho EH, Chang YH

Inversion of chromosome 16 [inv(16)(p13.1q22)] and t(16;16)(p13.1;q22) are associated with acute myelomonocytic leukemia (AMML) with eosinophilia and a favorable prognosis. On the other hand, patients with del(16)(q22) usually present with...
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Successful Desensitization to Epirubicin in a Breast Cancer Patient with Doxorubicin Hypersensitivity

  • KMID: 2234614
  • Korean J Asthma Allergy Clin Immunol.
  • 2009 Jun;29(2):127-131.
Doxorubicin, a chemotherapeutic agent of the anthracycline family, has commonly been used to treat a wide range of cancers including leukemia, Hodgkin's lymphoma, and cancers of the breast, uterus, ovary...
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Outcomes of a Modified CALGB 19802 Regimen in Adult Acute Lymphoblastic Leukemia

Han AR, Kim K, Jang JH, Kim WS, Ahn JS, Jung CW, Lee MH, Kang WK

We analyzed the efficacy and toxicity of a modified Cancer and Leukemia Group B (CALGB) 19802 regimen in adult acute lymphoblastic leukemia (ALL). From February 2002 to August 2005, 25...
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Relationship between In Vitro Chemosensitivity assessed with MTT Assay and Clinical Outcomes in 103 Patients with Acute Leukemia

Jun KR, Jang S, Chi HS, Lee KH, Lee JH, Choi SJ, Seo JJ, Moon HN, Im HJ, Park CJ

BACKGROUND: Cellular drug resistance is supposed to play a major role in chemotherapy failure or relapse. The purpose of this study was to analyze the relationship between in vitro...
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Ten-year Experience on Acute Promyelocytic Leukemia at Inha University Hospital

Yi HG, Lim JH, Kim JS, Park HJ, Moon Y, Lee MH, Nahm CH, Kim CS

BACKGROUND: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia in its morphology as well as molecular or genetic profiles, conferring a good prognosis owing to the...
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Stabilizing Microtubular Network Facilitates the Intracellular Growth of Orientia tsutsugamushi

Kim MK, Kim MJ, Lim BU, Kang JS

Microtubule network provides many intracellular microbes with an efficient way to move within host cells. Orientia tsutsugamushi move from the cell periphery to the microtubule organizing center (MTOC) by dynein-dependent...
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PC12 Cell Apoptosis Mediated by Reactive Oxygen Species with Various Agents is Reduced Effectively by Flavonoid Antioxidants

Joe S, Bae JA, Lee KY

  • KMID: 1883448
  • Chonnam Med J.
  • 2004 Dec;40(4):173-179.
Reactive oxygen species (ROS) has many biological roles. Apoptosis is also induced by ROS. In this study, we show the involvement of ROS on the PC12 cell apoptosis induced by...
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A Case of Coincident Multiple Myeloma and Nasal NK/T-Cell Lymphoma

Lee WS

  • KMID: 1637343
  • Korean J Hematol.
  • 2004 Sep;39(3):182-185.
The coexistence of non-Hodgkin's lymphoma and multiple myeloma is very rare and the coexistence of nasal NK/T-cell lymphoma and multiple myeloma has never been reported in the literature. Recently, a...
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Detection of Multidrug Resistance Using Molecular Nuclear Technique

Lee J, Ahn BC

  • KMID: 2078811
  • Korean J Nucl Med.
  • 2004 Apr;38(2):180-189.
Although the outcome of cancer patients after cytotoxic chemotherapy is related diverse mechanisms, multidrug resistance (MDR) for chemotherapeutic drugs due to cellular P-glycoprotein (Pgp) or multidrug-resistance associated protein (MRP) is...
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Diallyl Disulfide Enhances Daunorubicin-Induced Apoptosis of HL-60 Cells

Koo BS, Yang JY, Shon HS, Kwon KB, Jhee EJ

  • KMID: 1618395
  • Korean J Nutr.
  • 2003 Oct;36(8):828-833.
Dially disulfide (DADS), a component of garlic (Allium sativum), has been known to exert potent chemopreventive activity against various cancers. In this study, the synergistic effect of DADS and daunorubicin...
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A Case of Acute Panmyelosis with Myelofibrosis according to WHO Classification

Kang SY, Park CJ, Suh EJ, Lee GH, Chi HS

  • KMID: 2252408
  • Korean J Hematol.
  • 2003 Aug;38(3):195-199.
A 61-year-old man developed a rapidly progressive disease with anemia, thrombocytopenia and large number of blasts (10%) in the peripheral blood. The bone marrow revealed hypercellular marrow with extensive fibrosis...
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Relation among the Tests and Comparison of Positivity of Tests for Multi-Drug Resistance in Newly Diagnosed Acute Leukemia

Lee NY, Bae HG, Kwon EH, Heo WB, Shin SH, Suh JS

  • KMID: 2239566
  • Korean J Lab Med.
  • 2003 Jun;23(3):143-150.
BACKGROUND: The expression of multi-drug resistance (MDR) in acute leukemia was known to decrease the outcome of chemotherapy and to increase the rate of relapse. Of the mechanism of MDR,...
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The Relation between Acute Adriamycin induced Cardiomyopathy and Apoptosis in rat : Study using 15 MHz High Frequency Transducer

Choi YS, Park CS, Cho EJ, Jung HO, Jeon HK, Kang JH, Lee JH, Youn HJ, Chae JS, Kim JH, Cho KB, Hong SJ

  • KMID: 2408609
  • J Korean Soc Echocardiogr.
  • 2002 Dec;10(2):35-43.
BACKGROUND: Anthracyclines, such as daunorubicin or doxorubicin that are one of the most widely used as chemotherapeutic agents in oncology clinics have the limitation of its usage because of severe...
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