Korean J Nephrol.  1999 Jul;18(4):656-660.

A Case of Anti-Glomerular Basement Membrane Antibody Associated Crescentic Glomerulonephritis with Positive Antineutrophilic Cytoplasmic Antibody

• Lee KH
• Lee DR
• Kim KH
• Cho JH
• Kim DY
• Chung JS
• Kong JM
• Yun SH
• Kim BC

Abstract

A 63-year-old woman presented to the hospital with gross hematuria and acute renal failure. Kidney function deteriorated rapidly and progressively. A renal biopsy revealed segmental or circumferential crescents associated with linear deposits of immunoglobulin G, typical of anti-glomerular basement membrane disease. Both c-ANCA and anti-GBM antibody were detected in serum. She was treated with hemodialysis, plasmapheresis, high dose steroid and cyclophosphamide. However, she died 7 weeks after treatment because of pneumonia, without recovery of renal function. Serologic positivity of both ANCA and anti-GBM antibody are becoming more frequently recognized in rapidly progressive glomerulonephritis. The influence of c-ANCA on the clinical course of anti-GBM glomerulonephritis remains to be determined.

Keyword

Anti-GBM antibody; ANCA; Glomerulonephritis

MeSH Terms

Acute Kidney Injury
Anti-Glomerular Basement Membrane Disease
Antibodies, Antineutrophil Cytoplasmic
Basement Membrane*
Biopsy
Cyclophosphamide
Cytoplasm*
Female
Glomerulonephritis*
Hematuria
Humans
Immunoglobulin G
Kidney
Middle Aged
Plasmapheresis
Pneumonia
Renal Dialysis
Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide
Immunoglobulin G