Korean J Med.  2012 Nov;83(5):654-658.

A Case of Crescentic Glomerulonephritis with Coexisting Anti-Glomerular Basement Membrane Antibodies and Myeloperoxidase-Anti-Neutrophil Cytoplasmic Autoantibodies

Affiliations
  • 1Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea. jtcho@dankook.ac.kr
  • 2Department of Pathology, Dankook University College of Medicine, Cheonan, Korea.

Abstract

Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome involving abrupt or insidious onset of hematuria, proteinuria, and anemia, and rapidly progressive renal failure. Crescentic glomerulonephritis is a histopathological term for RPGN showing extensive extracapillary proliferation, i.e., crescent formation. There are three major immunopathological categories of crescentic glomerulonephritis: anti-glomerular basement membrane (anti-GBM) antibody disease, immune complex-mediated, and pauci-immune (anti-neutrophil cytoplasmic autoantibody [ANCA]-positive). A small minority of all patients with glomerulonephritis develop crescentic glomerulonephritis. Anti-GBM antibodies and ANCA rarely coexist. There have been a few reports of dual positive crescentic glomerulonephritis with anti-GBM antibodies and ANCA in Korea. Here, we describe the case of a 73-year-old woman showing RPGN clinically and crescentic glomerulonephritis pathologically with coexisting anti-GBM antibodies and myeloperoxidase-ANCA.

Keyword

Anti-glomerular basement membrane antibody; Glomerulonephritis; ANCA

MeSH Terms

Aged
Anemia
Antibodies
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Basement Membrane
Cytoplasm
Female
Glomerulonephritis
Hematuria
Humans
Immune System Diseases
Korea
Proteinuria
Renal Insufficiency
Antibodies
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
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