Korean J Nephrol.  2001 May;20(3):506-510.

A Case of Overlapping Syndrome of Primary IgA Nephropathy and Membranous Nephropathy

• Kim KH
• Ha YJ
• Hur JW
• Seo WJ
• Park CS
• Song JH
• Kim YJ

Abstract

We report a rare case of primary glomerular disease with overlapping IgA nephropathy and membranous nephropathy in a 52 year-old man. Clinically, The patient showed microscopic hematuria and proteinuria and had no underlying disorders such as hepatitis B, hepatitis C, drug exposure, SLE or other immunologic diseases. Histologically, glomeruli showed focal cellular proliferartione and electron deposits in the mesangium and concomittant subepithelial deposits. Immunofluorescence revealed IgA depositions in a mesangium and IgG depositions along the glomerular capillary walls, like those of typical membranous nephropathy. These findings suggest the primary glomerular disease overlapping of two different glomerular changes. The patient showed still persistent proteinuria, but have preserved renal function with administrations of ACE inhibitors and diuretics after two years.

Keyword

IgA nephropathy; Membranous nephropathy; Primary; Overlapping nephropathy

MeSH Terms

Angiotensin-Converting Enzyme Inhibitors
Capillaries
Diuretics
Fluorescent Antibody Technique
Glomerulonephritis, IGA*
Glomerulonephritis, Membranous*
Hematuria
Hepatitis B
Hepatitis C
Humans
Immune System Diseases
Immunoglobulin A*
Immunoglobulin G
Middle Aged
Proteinuria
Angiotensin-Converting Enzyme Inhibitors
Diuretics
Immunoglobulin A
Immunoglobulin G