Korean J Nephrol.  1998 Jul;17(4):624-628.

A Case of Overlapping Syndrome of Primary Membranous Nephropathy and IgA Nephropathy

• Kim TS
• Cha MK
• Lee JH
• Ha SY

Abstract

We report a rare case of primary glomerular disease with both features of IgA nephropathy and membranous glomerulonephritis in a 27 year-old woman with nephrotic syndrome. Histologically, glomeruli showed slight mesangial expansion, proliferation of mesangial cells, and short subepithelial spikes on capillary wall. Direct immunofluorescence demonstrated granular IgG and C3 deposits along the capillary walls, and IgA with C3 deposits in mesangium. Granular subepithelial and rnesangial deposits were observed by electron microscopy. The patient showed complete remission after 6 months therapy with steroid and ACE inhibitor.

Keyword

IgA nephropathy; Membranous nephropathy; Overlapping glomerulonephritis

MeSH Terms

Adult
Capillaries
Female
Fluorescent Antibody Technique, Direct
Glomerulonephritis, IGA*
Glomerulonephritis, Membranous*
Humans
Immunoglobulin A*
Immunoglobulin G
Mesangial Cells
Microscopy, Electron
Nephrotic Syndrome
Immunoglobulin A
Immunoglobulin G