Cancer Res Treat.  2012 Sep;44(3):151-156.

Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer

Affiliations
  • 1Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan. fariz@juntendo.ac.jp

Abstract

Among all types of cancer, incidence of lung cancer remains the highest with regard to cancer-related mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in cancer progression. EMT is a critical mechanism ensuring tissue remodeling during morphogenesis of multicellular organisms. Therefore, understanding of the biology of this process for identification of potential EMT-targeted therapeutic strategies for the benefit cancer patients is necessary. This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer.

Keyword

Epithelial-mesenchymal transition; Drug resistance; Neoplasm metastasis; Lung neoplasms

MeSH Terms

Biology
Drug Resistance
Epithelial-Mesenchymal Transition
Humans
Incidence
Lung
Lung Neoplasms
Morphogenesis
Neoplasm Metastasis
Recurrence
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