J Korean Child Neurol Soc.  2013 Sep;21(3):170-175.

A Case of Japanese Encephalitis Presenting with Fever and Seizure in a 7-month old Infant

• Kim SY
• Kim JS
• Lee HJ
• Kim H
• Lim BC
• Hwang H
• Chae JH
• Choi J
• Kim KJ
• Hwang YS

Abstract

Japanese encephalitis is one of the leading causes of acute encephalitis in Asia. But in Korea, the number of Japanese encephalitis cases has dropped considerably due to mass vaccination and vector control. Especially, there were no case reports under the age of 9 years during the last ten years. We will describe a case of a previously healthy 7-month old boy who presented with fever and seizure. The patient was diagnosed with Japanese encephalitis, based on the cerebrospinal fluid and serum antibody analyses for the Japanese encephalitis virus. Typical brain magnetic resonance image findings of Japanese encephalitis were observed. The patient received extensive conservative treatment including high dose intravenous corticosteroid treatment and immunoglobulin. In spite of severe hemodynamic instability, the patient survived, and he is currently in a vegetative state with respiratory assist by a home ventilator. Although the incidence of Japanese encephalitis dropped dramatically in Korea, pediatricians should always consider the diagnosis as one of the possibilities for patients with encephalitis, especially if the patient is not immunized for JEV. Since there is no specific treatment for JEV, timely and comprehensive conservative care is critical to reduce the mortality and morbidity.

Keyword

Japanese encephalitis; pediatric; corticosteroid; immunoglobulin

MeSH Terms

Asia
Asian Continental Ancestry Group*
Brain
Cerebrospinal Fluid
Diagnosis
Encephalitis
Encephalitis Virus, Japanese
Encephalitis, Japanese*
Fever*
Hemodynamics
Humans
Immunoglobulins
Incidence
Infant*
Korea
Male
Mass Vaccination
Mortality
Persistent Vegetative State
Seizures*
Ventilators, Mechanical
Immunoglobulins