J Korean Acad Periodontol.  1997 Mar;27(1):249-262. 10.5051/jkape.1997.27.1.249.

The Effects of Calcium sulfate Membrane on the Periodontal Wound Repair of Horizontal Dehiscence defects in Dogs

• Choi SH
• Cho KS
• Moon IS
• Chai JK
• Kim CK

• KMID: 1959428
• DOI: http://doi.org/10.5051/jkape.1997.27.1.249

Abstract

The present study investigates the effects of calcium sulfate graft on the periodontal healing in intrabony periodontal defects of dogs. Following the general anesthesia with 30mg/kg pentobarbital injected intravenously, the first premolar was extracted and full-thickness periodontal flap was elevated from the second premolar to the fourth premolar. The portion of premolars coronal to the alveolar crest was removed and mesial and distal roots were separated. Exposed root canals were sealed with Caviton and covered completely with flaps sutured. Following the healing period of 12 weeks, the surgical sited were uncovered and 4x4mm intrabony defects were surgically created. Those defects with calcium sulfate graft following the root planing was designated as the test sites and those with flap surgery-only were designated as control sites. The animals were sacrificed after 8 weeks and the healing was histologically analyzed. The results were as follows. 1. No foreign body reaction or inflammation were observed in either groups. Calcium sulfate was completely resorbed in the test sites. 2. New cementum was observed coronal to the notch in both groups. Connective tissue fibers were oriented parallel to the root surface in the controls. Connective tissues were formed in large amount in the sites. 3. Test sites showed marked amount of new bone formation while the control sites showed minimal bone gain. 4. Root resorption was observed in coronal portions of th control sites. The results suggest that calcium sulfate is a biocompatible graft material with a potential for new bone and cementum formation.

Keyword

Calcium sulfate; Membrane; Wound repair; Dehiscence defects

MeSH Terms

Anesthesia, General
Animals
Bicuspid
Calcium Sulfate*
Calcium*
Connective Tissue
Dental Cementum
Dental Pulp Cavity
Dogs*
Foreign-Body Reaction
Inflammation
Membranes*
Osteogenesis
Pentobarbital
Root Planing
Root Resorption
Transplants
Wounds and Injuries*
Calcium
Calcium Sulfate
Pentobarbital