Korean Circ J.  2004 Jan;34(1):35-40. 10.4070/kcj.2004.34.1.35.

The Effectiveness of Carvedilol, a New Antioxidant and Antiproliferative Beta-Blocker, on Prevention of Restenosis after Coronary Stent Implantation: a Prospective, Randomized, Multicenter Study

• Cha KS
• Kim MH
• Kim JW
• Kim DI
• Kim HJ
• Kim YD
• Kim DS
• Kim JS

• KMID: 1938851
• DOI: http://doi.org/10.4070/kcj.2004.34.1.35

Abstract

BACKGROUND
Carvedilol is a direct inhibitor of vascular smooth muscle cell migration and proliferation through inhibition of mitogen-activated protein kinase activity and regulation of cell cycle progression. It produced an 84% suppression of neointimal hyperplasia in rat carotid angioplasty model, but no data are available regarding its effect on stent restenosis in patients. We tested whether a sustained oral administration of carvedilol reduces restenosis after coronary stenting in patients.
METHODS
One hundred fifty nine patients were randomized to receive either carvedilol (50 mg/day, n=80) or atenolol (50 mg/day, n=79) at least 1 day before stenting and continued on the same medication over 3 months. The primary end point was angiographic restenosis (>50% diameter stenosis) at follow-up angiography.
RESULTS
Baseline clinical and angiographic variables were similar between the carvedilol and atenolol group. The carvedilol dose was tolerable in most patients after adjustment of other medications, but reduced in 3 patients due to hypotension and dizziness. Angiographic follow-up was done in 137 patients (86%) and the restenosis rate was not different significantly between both groups (17.1% versus 19.4%, p=0.732).
CONCLUSION
A sustained oral administration of carvedilol is not effective to reduce stent restenosis. With carvedilol targeting regulators of cell cycle progression and having a profound neointimal inhibition with a high blood concentration in an experiment, further investigations using a stent-based delivery to achieve a high local concentration may be warranted.

Keyword

Carvedilol; Stents; Coronary restenosis; Drug therapy

MeSH Terms

Administration, Oral
Angiography
Angioplasty
Animals
Atenolol
Cell Cycle
Cell Movement
Coronary Restenosis
Dizziness
Drug Therapy
Follow-Up Studies
Humans
Hyperplasia
Hypotension
Muscle, Smooth, Vascular
Prospective Studies*
Protein Kinases
Rats
Stents*
Atenolol
Protein Kinases