Korean J Anesthesiol.  2014 Oct;67(4):252-257. 10.4097/kjae.2014.67.4.252.

The effects of intravenous dexmedetomidine on spinal anesthesia: comparision of different dose of dexmedetomidine

• Lee MH
• Ko JH
• Kim EM
• Cheung MH
• Choi YR
• Choi EM

• KMID: 1937684
• DOI: http://doi.org/10.4097/kjae.2014.67.4.252

Abstract

BACKGROUND
In this prospective, randomized, double-blind, placebo-controlled trial, we tried to find out appropriate amounts of single-dose dexmedetomidine to prolong the duration of spinal anesthesia in a clinical setting.
METHODS
Sixty patients who were scheduled for unilateral lower limb surgery under spinal anesthesia were randomized into three groups receiving normal saline (control group, n = 20) or 0.5 or 1.0 ug/kg dexmedetomidine (D-0.5 group, n = 20; D-1, n = 20) intravenously prior to spinal anesthesia with 12 mg of bupivacaine. The two-dermatome pinprick sensory regression time, duration of the motor block, Ramsay sedation score (RSS), and side effects of dexmedetomidine were assessed.
RESULTS
The two-dermatome pinprick sensory regression time (57.6 +/- 23.2 vs 86.5 +/- 24.3 vs 92.5 +/- 30.7, P = 0.0002) and duration of the motor block (98.8 +/- 34.1 vs 132.9 +/- 43.4 vs 130.4 +/- 50.4, P = 0.0261) were significantly increased in the D-0.5 and D-1 groups than in the control group. The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group. However, there were no patients with oxygen desaturation in dexmedetomidine groups. The incidences of hypotension and bradycardia showed no differences among the three groups.
CONCLUSIONS
Both 0.5 and 1.0 ug/kg of dexmedetomidine administered as isolated boluses in the absence of maintenance infusions prolonged the duration of spinal anesthesia.

Keyword

Bupivacaine; Dexmedetomidine; Spinal anesthesia

MeSH Terms

Anesthesia, Spinal*
Bradycardia
Bupivacaine
Dexmedetomidine*
Humans
Hypotension
Incidence
Lower Extremity
Oxygen
Prospective Studies
Bupivacaine
Dexmedetomidine
Oxygen