Korean J Med.  2001 Apr;60(4):314-323.

The inhibitory effect of platelet glycoprotein IIb/IIIa receptor blocker-coated stent on porcine coronary stent restenosis

• Kang KT
• Jeong MH
• Kim NH
• Rhew JY
• Lee SH
• Park JC
• Lee SU
• Kim KH
• Choi MJ
• Ahn YK
• Cho JG
• Park JC
• Choi WJ
• Cho DL
• Park JT
• Kang JC

Abstract

BACKGROUND: The problems of coronary stent thrombosis and restenosis still remain to be solved.The glycoprotein IIb/IIIa receptor blocker, Abciximab (ReoPro), plays important roles in the treatment of high-risk patient with acute platelet-rich thrombus and in the inhibition of smooth muscle cell proliferation. The aim of this study was to determine whether the use of ReoPro-coated stents could reduce the neointimal formation in a porcine coronary stent restenosis model.
METHODS
ReoPro was coated on the surface of stent by means of plasma polymerization followed by chemical grafting. Stent overdilation injury was performed with control bare stent (Group I, n=13), and ReoPro-coated stents (Group II, n=14). Follow-up quantitative coronary angiogram was performed at 4 weeks after stenting and histopathologic assessment were compared in both groups.
RESULTS
The diameter stenosis by QCA between two groups was significantly higher in Group I (23+/-5 % vs. 15+/-7 %, p=0.003). On histopathologic examination, no in-stent thrombus was observed. The percent area stenosis was significantly higher in Group I than in Group II (48+/-17 % vs. 30+/-16 %, p=0.01). The area of neoinima was larger in Group I than in Group II (3.2+/-1.2 mm2 vs. 2.0+/-1.0 mm2, p=0.01). By immunocytochemistry, proliferation cell nuclear antigen indices were higher in Group I (4.2+/-2.1 %, vs 2.4+/-1.8 % p=0.03).
CONCLUSION
The ReoPro-coated stent is safe and effective in the prevention of in-stent thrombus and restenosis, which may be related with the inhibition of platelet thrombus and neointimal cell proliferation.

Keyword

Restenosis; Stents; Platelet; Glycoprotein IIb/IIIa Integrin; Thrombus; Neointima; Proliferation

MeSH Terms

Blood Platelets*
Cell Proliferation
Constriction, Pathologic
Follow-Up Studies
Glycoproteins*
Humans
Immunohistochemistry
Myocytes, Smooth Muscle
Neointima
Plasma
Polymerization
Polymers
Stents*
Thrombosis
Transplants
Glycoproteins
Polymers